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Recombinant Human BCL6 Protein, GST-tagged

Cat.No. : BCL6-158H
Product Overview : Recombinant human BCL6 protein with a GST-tag was expressed in E. coli
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Source : E. coli
Species : Human
Tag : GST
Molecular Mass : The protein has a calculated MW of 43 kDa.
AA Sequence : MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLVPRG SPEFMASPADSCIQFTRHASDVLLN LNRLRSRDILTDVVIVVSREQFRAH KTVLMACSGLFYSIFTDQLKCNLSV INLDPEINPEGFCILLDFMYTSRLN LREGNIMAVMATAMYLQMEHVVDTC RKFIKASEAEMVSAIKPPREEFLNS RMLM
Purity : >90% by SDS-PAGE
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Concentration : 0.629 mg/mL
Storage Buffer : 50mM Tris, 10mM GSH pH7.5
Gene Name : BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens (human) ]
Official Symbol : BCL6
Synonyms : BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; ZNF51;
Gene ID : 604
mRNA Refseq : NM_001130845
Protein Refseq : NP_001124317
MIM : 109565
UniProt ID : P41182

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the current challenges in targeting BCL6 protein for therapeutic purposes? 02/21/2023

Challenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.

Are there any known genetic mutations or alterations in the BCL6 gene associated with disease susceptibility? 10/07/2022

Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.

What role does BCL6 protein play in the germinal center reaction? 06/13/2022

BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.

How might targeting BCL6 protein offer new therapeutic options for autoimmune diseases? 06/30/2021

Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.

Can the assessment of BCL6 protein expression aid in the prognosis of lymphoma patients? 05/22/2017

Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.

Customer Reviews (3)

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04/21/2022

    Its stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.

    09/22/2021

      I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis

      12/11/2016

        Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.

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