Recombinant Human BIRC2 protein, His-tagged BIRC2-01H

September 27-30, 2022

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Recombinant Human BIRC2 protein, His-tagged


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Cat.No. : BIRC2-01H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human BIRC2 protein, fused to His-tag, was expressed in E. coli.
Description : cIAP-1 (also known as MIHB and HIAP-2) is a member of the inhibitor of apoptosis (IAP) family of proteins that inhibit the proteolytic activity of mature caspases. cIAP-1 has 3 BIR (baculovirus inhibitor of apoptosis) domains, a RING finger domain, and a caspase recruitment domain (CARD). cIAP-1 inhibits caspases by interaction of the BIR domain with the active caspase. Caspase activity may be restored through interactions with the Reaper like motif on mitochondrial proteins such as SMAC/Diablo or HTRA-2/Omi. cIAP-1 is reported to be cleaved by caspases in fetal rat hepatocytes treated with TGF-beta.
Source : E. coli
Species : Human
Tag : His
Form : Supplied as a 0.2 μm filtered solution in HEPES, NaCl, DTT and Glycerol.
Bio-activity : Measured by its ability to inhibit DEVD-AFC cleavage activity in cell extracts activated by addition of cytochrome c and dATP. The IC50 for this effect is 25-1000 nM.
Molecular Mass : Predicted Molecular Mass:72 kDa
SDS-PAGE: 68 kDa, reducing conditions
N-terminal Sequence Analysis : Ala
Purity : >85%
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -70 centigrade as supplied.
3 months, -70 centigrade under sterile conditions after opening.
Shipping : The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : BIRC2 baculoviral IAP repeat containing 2 [ Homo sapiens (human) ]
Official Symbol : BIRC2
Synonyms : API1Hiap-2; apoptosis inhibitor 1; baculoviral IAP repeat containing 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing protein 2; BIRC2; cIAP1; c-IAP1; cIAP-1; hIAP2; HIAP-2; IAP homolog B; IAP2; IAP-2; Inhibitor of apoptosis protein 2; MIHB; MIHBHIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RNF48hiap-2; TNFR2-TRAF-signaling complex protein 2
Gene ID : 329
mRNA Refseq : NM_001166.5
Protein Refseq : NP_001157.1
MIM : 601712
UniProt ID : Q13490
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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