Recombinant Human BIRC7 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BIRC7-4174H
• Product Overview: BIRC7 MS Standard C13 and N15-labeled recombinant protein (NP_647478) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 32.8 kDa
• AA Sequence: MGPKDSAKCLHRGPQPSHWAAGDGP TQERCGPRSLGSPVLGLDTCRAWDH VDGQILGQLRPLTEEEEEEGAGATL SRGPAFPGMGSEELRLASFYDWPLT AEVPPELLAAAGFFHTGHQDKVRCF FCYGGLQSWKRGDDPWTEHAKWFPS CQFLLRSKGRDFVHSVQETHSQLLG SWDPWEEPEDAAPVAPSVPASGYPE LPTPRREVQSESAQEPGGVSPAQAQ RAWWVLEPPGARDVEAQLRRLQEER TCKVCLDRAVSIVFVPCGHLVCAEC APGLQLCPICRAPVRSRVRTFLSTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ]
• Official Symbol: BIRC7
• Synonyms: BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 50; LIVIN; MLIAP; ML-IAP
• Gene ID: 79444
• mRNA Refseq: NM_139317
• Protein Refseq: NP_647478
• MIM: 605737
• UniProt ID: Q96CA5