Recombinant Human BMPR2 Protein, Fc/His-tagged
Cat.No. : | BMPR2-870H |
Product Overview : | Recombinant Human BMPR2 fused with Fc/His tag at C-terminal was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. |
Source : | HEK293 cells |
Tag : | Fc/His |
Form : | Lyophilized from a 0.2 µM filtered solution of PBS, pH 7.4 |
Molecular Mass : | 41.9kD |
AA Sequence : | SQNQERLCAFKDPYQQDLGIGESRI SHENGTILCSKGSTCYGLWEKSKGD INLVKQGCWSHIGDPQECHYEECVV TTTPPSIQNGTYRFCCCSTDLCNVN FTENFPPPDTTPLSPPHSFNRDETI VDDIEGRMDEPKSCDKTHTCPPCPA PELLGGPSVFLFPPKPKDTLMISRT PEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVL TVLHQDWLNGKEYKCKVSNKALPAP IEKTISKAKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVEW ESNGQPENNYKTTPPVLDSDGSFFL YSKLTVDKSRWQQGNVFSCSVMHEA LHNHYTQKSLSLSPGKHHHHHH |
Endotoxin : | Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
Purity : | >95% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) [ Homo sapiens ] |
Official Symbol : | BMPR2 |
Synonyms : | BMPR2; bone morphogenetic protein receptor, type II (serine/threonine kinase); PPH1, primary pulmonary hypertension 1; bone morphogenetic protein receptor type-2; BMPR II; BMPR3; BRK 3; T ALK; BMPR-2; BMP type-2 receptor; BMP type II receptor; type II activin receptor-like kinase; bone morphogenetic protein receptor type II; type II receptor for bone morphogenetic protein-4; BMR2; PPH1; BRK-3; T-ALK; BMPR-II; FLJ41585; FLJ76945; |
Gene ID : | 659 |
mRNA Refseq : | NM_001204 |
Protein Refseq : | NP_001195 |
MIM : | 600799 |
UniProt ID : | Q13873 |
Products Types
◆ Recombinant Protein | ||
BMPR2-1060M | Recombinant Mouse BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Bmpr2-715M | Recombinant Mouse Bmpr2 Protein, MYC/DDK-tagged | +Inquiry |
BMPR2-2707H | Recombinant Human BMPR2 Protein, MYC/DDK-tagged | +Inquiry |
BMPR2-377R | Recombinant Rhesus Macaque BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BMPR2-451H | Recombinant Human BMPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
BMPR2-2717HCL | Recombinant Human BMPR2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionBMPR2 plays a significant role in PAH, influencing vascular cell proliferation and vascular remodeling.
Mutations in BMPR2 contribute to hereditary hemorrhagic telangiectasia, impacting vascular development.
Changes in BMPR2 signaling impact embryonic development, potentially resulting in congenital anomalies.
Dysregulation of BMPR2 affects renal function, potentially leading to kidney disease and dysfunction.
BMPR2 is key in bone morphogenetic protein signaling, crucial for bone growth and remodeling.
BMPR2 is involved in cardiovascular development, particularly affecting heart valve formation and function.
BMPR2 regulates cell proliferation and apoptosis, playing a role in tissue homeostasis.
Customer Reviews (3)
Write a reviewHigh-quality protein crystallography services, exceptional outcomes.
Critical expertise in protein engineering, unmatched service quality.
Swift and reliable protein sequencing, invaluable for our research.
Ask a Question for All BMPR2 Products
Required fields are marked with *
My Review for All BMPR2 Products
Required fields are marked with *
Inquiry Basket