Recombinant Human BTK (R562W) Mutant Protein, GST-tagged

• Cat.No.: BTK-06H
• Product Overview: Recombinant full-length human BTK (R562W) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Insect cell
• Species: Human
• Tag: GST
• Molecular Mass: Approx 101 kDa
• Purity: > 80%
• Stability: One year at -70 centigrade from data of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 μg/μL
• Storage Buffer: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: BTK Bruton tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: BTK
• Synonyms: BTK; Bruton tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; IGHD3; PSCTK1; tyrosine-protein kinase BTK; B-cell progenitor kinase; Bruton agammaglobulinemia tyrosine kinase; Bruton's tyrosine kinase; agammaglobulinaemia tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; truncated Bruton agammaglobulinemia tyrosine kinase; EC 2.7.10.2
• Gene ID: 695
• mRNA Refseq: NM_000061
• Protein Refseq: NP_000052
• MIM: 300300
• UniProt ID: Q06187