| Description : |
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 and bind to clathrin and clathrin adaptor protein-2. Thus, connecdenns link RAB35 activation with the clathrin machinery. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
37.3 kDa |
| AA Sequence : |
MTKATPAVRTAYKFAKNHAKLGLKE VKSKLKHKENEEDYGTCSSSVQYTP VYKLHNEKGGNSEKRKLAQARLKRP LKSLDGALYDDEDDDDIERASKLSS EDGEEASAYLYESDDSVETRVKTPY SGEMDLLGEILDTLSTHSSDQGKLA AAKSLDFFRSMDDIDYKPTNKSNAP SENNLAFLCGGSGDQAEWNLGQDDS ALHGKHLPPSPRKRVSSSGLTDSLF ILKEENSNKHLGADNVSDPTSGLDF QLTSPEVSQTDKGKTEKRETLSQIS DDLLIPGLGRHSSTFVPWEKEGKEA KETSEDIGLLHEVVSLCHMTSDFQQ SLNISDKNTNGNQTTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
