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Recombinant Human C4B Protein, His-tagged

Cat.No. : C4B-340H
Product Overview : Recombinant Human C4B Protein (Gln19-Leu333) with N-His tag was expressed in E. coli.
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Description : This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.
Source : E. coli
Species : Human
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 39.1 kDa
Accurate Molecular Mass: 39 kDa
Protein length : Gln19-Leu333
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : C4B complement component 4B, telomeric [ Homo sapiens (human) ]
Official Symbol : C4B
Synonyms : C4B; complement component 4B, telomeric; C4A; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4A91; C4B12
Gene ID : 721
mRNA Refseq : NM_001002029
Protein Refseq : NP_001002029
MIM : 120820
UniProt ID : P0C0L5

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the clinical applications of C4B inhibitors? 09/23/2022

C4B inhibitors can be used to treat diseases associated with complement hyperactivation, such as autoimmune diseases and graft-versus-host disease. By inhibiting the activity of C4B, it is possible to attenuate the excessive inflammatory response and tissue damage.

How is the expression level of C4B regulated? 12/02/2021

The expression level of C4B is regulated by a variety of factors, including inflammatory factors, cytokines, and drugs. These factors can affect the synthesis and release of C4B, thus affecting its function in the immune system.

Is C4B involved in the formation and clearance of immune complexes? 01/05/2021

It can bind to other complement components and immunoglobulins to form immune complexes. These immune complexes can be recognized and cleared by clearance mechanisms in the body, such as phagocytes.

Is there a relationship between C4B and other immune system components? 07/12/2020

It is closely related to other immune system components (such as T cells, B cells, antibodies, etc.) and is involved in the immune defense response in the body. The interactions and influences between them are important for maintaining immune homeostasis.

How does C4B function differently in different cell types? 05/26/2020

The role of C4B in different types of cells may vary. For example, in immune cells, it can be involved in the regulation of immune responses and cell activation, while in endothelial cells, it may be involved in the process of vascular inflammation and injury.

How does C4B interact with other complement components? 02/24/2020

C4B interacts with other complement components (e.g., C4A, C2, C3, etc.) to form part of the complement activation pathway and is involved in the immune defense response.

Customer Reviews (3)

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Reviews
09/05/2021

    C4B labeling works very well and can be fluorescently labeled, etc., which is very suitable for our research.

    02/04/2021

      In experiments, biocompatibility showed up very well.

      10/28/2020

        Very good at western-blot experimenting.

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