Recombinant Human C4B Protein, His-tagged
Cat.No. : | C4B-340H |
Product Overview : | Recombinant Human C4B Protein (Gln19-Leu333) with N-His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. |
Source : | E. coli |
Species : | Human |
Tag : | N-His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 39.1 kDa Accurate Molecular Mass: 39 kDa |
Protein length : | Gln19-Leu333 |
Purity : | > 90% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | C4B complement component 4B, telomeric [ Homo sapiens (human) ] |
Official Symbol : | C4B |
Synonyms : | C4B; complement component 4B, telomeric; C4A; C4F; CO4; C4B1; C4B2; C4B3; C4B5; C4A91; C4B12 |
Gene ID : | 721 |
mRNA Refseq : | NM_001002029 |
Protein Refseq : | NP_001002029 |
MIM : | 120820 |
UniProt ID : | P0C0L5 |
Products Types
◆ Recombinant Protein | ||
C4B-0051H | Recombinant Human C4B Protein, GST-Tagged | +Inquiry |
C4b-342R | Recombinant Rat C4b Protein, His-tagged | +Inquiry |
C4B-341H | Recombinant Human C4B Protein, His-tagged | +Inquiry |
C4b-0053M | Recombinant Mouse C4b Protein, GST-Tagged | +Inquiry |
C4B-343H | Recombinant Human C4B Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
C4B-1846H | Native Human C4B Protein | +Inquiry |
C4B-99H | Native Human C4b Binding Protein | +Inquiry |
C4B-10H | Native Human C4B Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionC4B inhibitors can be used to treat diseases associated with complement hyperactivation, such as autoimmune diseases and graft-versus-host disease. By inhibiting the activity of C4B, it is possible to attenuate the excessive inflammatory response and tissue damage.
The expression level of C4B is regulated by a variety of factors, including inflammatory factors, cytokines, and drugs. These factors can affect the synthesis and release of C4B, thus affecting its function in the immune system.
It can bind to other complement components and immunoglobulins to form immune complexes. These immune complexes can be recognized and cleared by clearance mechanisms in the body, such as phagocytes.
It is closely related to other immune system components (such as T cells, B cells, antibodies, etc.) and is involved in the immune defense response in the body. The interactions and influences between them are important for maintaining immune homeostasis.
The role of C4B in different types of cells may vary. For example, in immune cells, it can be involved in the regulation of immune responses and cell activation, while in endothelial cells, it may be involved in the process of vascular inflammation and injury.
C4B interacts with other complement components (e.g., C4A, C2, C3, etc.) to form part of the complement activation pathway and is involved in the immune defense response.
Customer Reviews (3)
Write a reviewC4B labeling works very well and can be fluorescently labeled, etc., which is very suitable for our research.
In experiments, biocompatibility showed up very well.
Very good at western-blot experimenting.
Ask a Question for All C4B Products
Required fields are marked with *
My Review for All C4B Products
Required fields are marked with *
Inquiry Basket