Recombinant Human C9, GST-tagged

• Cat.No.: C9-26247TH
• Product Overview: Recombinant Human C9 full-length ORF (22 a.a. - 559 a.a) fussed with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC).The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 84.92 kDa
• AA Sequence: QYTTSYDPELTESSGSASHIDCRMS PWSEWSQCDPCLRQMFRSRSIEVFG QFNGKRCTDAVGDRRQCVPTEPCED AEDDCGNDFQCSTGRCIKMRLRCNG DNDCGDFSDEDDCESEPRPPCRDRV VEESELARTAGYGINILGMDPLSTP FDNEFYNGLCNRDRDGNTLTYYRRP WNVASLIYETKGEKNFRTEHYEEQI EAFKSIIQEKTSNFNAAISLKFTPT ETNKAEQCCEETASSISLHGKGSFR FSYSKNETYQLFLSYSSKKEKMFLH VKGEIHLGRFVMRNRDVVLTTTFVD DIKALPTTYEKGEYFAFLETYGTHY SSSGSLGGLYELIYVLDKASMKRKG VELKDIKRCLGYHLDVSLAFSEISV GAEFNKDDCVKRGEGRAVNITSENL IDDVVSLIRGGTRKYAFELKEKLLR GTVIDVTDFVNWASSINDAPVLISQ KLSPIYNLVPVKMKNAHLKKQNLER AIEDYINEFSVRKCHTCQNGGTVIL MDGKCLCACPFKFEGIACEISKQKI SEGLPALEFPNEK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: C9 complement component 9 [ Homo sapiens ]
• Official Symbol: C9
• Synonyms: C9D; ARMD15; complement component C9
• Gene ID: 735
• mRNA Refseq: NM_001737
• Protein Refseq: NP_001728
• MIM: 120940
• UniProt ID: P02748
• Chromosome Location: 5p14-p12
• Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Complement Activation, Classical Pathway, organism-specific biosystem

Reviews

05/23/2021

Accurate protein structural analysis, indispensable for our investigations.

04/29/2021

Exceptional protein expression optimization support, highly appreciated.

10/08/2020

Reliable mass spectrometry analysis, pivotal for advancing proteomics research.

Q&As

What role does C9 play in mediating inflammation and protecting against bacterial infections?

C9 mediates inflammation and is key in defense against bacterial infections.

How does complement component C9 contribute to the formation of the membrane attack complex (MAC) in the immune response?

C9 is crucial in forming the MAC, which lyses pathogens and damaged cells in immune defense.

What are the mechanisms by which C9 interacts with other complement components in the cascade?

C9 interacts with other complement components to propagate the complement cascade and immune response.

How do alterations in C9 expression or function affect the balance of immune system regulation?

Variations in C9 function or expression can disrupt immune regulation, affecting disease susceptibility and severity.

How does C9 deficiency affect susceptibility to recurrent bacterial infections?

C9 deficiency increases vulnerability to recurrent bacterial infections due to weakened immune response.

How does C9 influence the outcome of ischemic injury and tissue damage?

C9 influences ischemic injury outcomes by mediating inflammatory and immune responses.

What is the impact of C9 on autoimmune diseases, particularly in relation to excessive complement activation?

In autoimmune diseases, C9 can exacerbate symptoms by overactivating the complement system.