Description : |
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
59.6 kDa |
AA Sequence : |
MSSCVSSQPSSNRAAPQDELGGRGS SSSESQKPCEALRGLSSLSIHLGME SFIVVTECEPGCAVDLGLARDRPLE ADGQEVPLDSSGSQARPHLSGRKLS LQERSQGGLAAGGSLDMNGRCICPS LPYSPVSSPQSSPRLPRRPTVESHH VSITGMQDCVQLNQYTLKDEIGKGS YGVVKLAYNENDNTYYAMKVLSKKK LIRQAGFPRRPPPRGTRPAPGGCIQ PRGPIEQVYQEIAILKKLDHPNVVK LVEVLDDPNEDHLYMVFELVNQGPV MEVPTLKPLSEDQARFYFQDLIKGI EYLHYQKIIHRDIKPSNLLVGEDGH IKIADFGVSNEFKGSDALLSNTVGT PAFMAPESLSETRKIFSGKALDVWA MGVTLYCFVFGQCPFMDERIMCLHS KIKSQALEFPDQPDIAEDLKDLITR MLDKNPESRIVVPEIKLHPWVTRHG AEPLPSEDENCTLVEVTEEEVENSV KHIPSLATVILVKTMIRKRSFGNPF EGSRREERSLSAPGNLLTKQGSEDN LQGTDPPPVGEEEVLLTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |