Recombinant Human CASP1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | CASP1-3737H |
Product Overview : | CASP1 MS Standard C13 and N15-labeled recombinant protein (NP_150636) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 29.6 kDa |
AA Sequence : | MADKVLKEKRKLFIRSMGEAPQAVQ DNPAMPTSSGSEGNVKLCSLEEAQR IWKQKSAEIYPIMDKSSRTRLALII CNEEFDSIPRRTGAEVDITGMTMLL QNLGYSVDVKKNLTASDMTTELEAF AHRPEHKTSDSTFLVFMSHGIREGI CGKKHSEQVPDILQLNAIFNMLNTK NCPSLKDKPKVIIIQACRGDNVSWR HPTMGSVFIGRLIEHMQEYACSCDV EEIFRKVRFSFEQPDGRAQMPTTER VTLTRCFYLFPGHTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | CASP1 caspase 1 [ Homo sapiens (human) ] |
Official Symbol : | CASP1 |
Synonyms : | CASP1; caspase 1, apoptosis-related cysteine peptidase; caspase 1, apoptosis related cysteine peptidase (interleukin 1, beta, convertase), caspase 1, apoptosis related cysteine protease (interleukin 1, beta, convertase), IL1BC; caspase-1; caspase 1; ICE; interleukin 1; beta; convertase; IL1B-convertase; CASP1 nirs variant 1; IL-1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); P45; IL1BC; |
Gene ID : | 834 |
mRNA Refseq : | NM_033294 |
Protein Refseq : | NP_150636 |
MIM : | 147678 |
UniProt ID : | P29466 |
Products Types
◆ Recombinant Protein | ||
CASP1-0411H | Recombinant Human CASP1 Protein, GST-Tagged | +Inquiry |
CASP1-1240M | Recombinant Mouse CASP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
CASP1-621H | Recombinant Human CASP1 Protein, His-tagged | +Inquiry |
Casp1-0413M | Active Recombinant Mouse Casp1 Protein | +Inquiry |
CASP1-1266H | Recombinant Human CASP1 Protein (N120-D297, A317-H404), His tagged | +Inquiry |
◆ Lysates | ||
CASP1-7841HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
CASP1-7840HCL | Recombinant Human CASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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