| Description : |
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
84.8 kDa |
| AA Sequence : |
MSQPGQKPAASPRPRRAAAARRTHE HVSEKTSESPSKPGEKKGSDEKKAA SLGSSQSSRTYAGGTASATKVSASS GATSKSSSMNPTETKAIPVSQQMEG PHLPNKKKHKKQAVKTEPEKKSQST KLSVVHEKKSQEGKPKEHTEPKSLP KQASDTGSNDAHNKKAVSRSAEQQP SEKSTEPKTKPQDMISAGGESVAGI TAISGKPGDKKKEKKSLTPAVPVES KPDKPSGKSGMDAALDDLIDTLGGP EETEEENTTYTGPEVSDPMSSTYIE ELGKREVTIPPKYRELLAKKEGITG PPADSSKPIGPDDAIDALSSDFTCG SPTAAGKKTEKEESTEVLKAQSSGT VRSAAPPQEKKRKVEKDTMSDQALE ALSASLGTRQAEPELDLRSIKEVDE AKAKEEKLEKCGEDDETIPSEYRLK PATDKDGKPLLPEPEEKPKPRSESE LIDELSEDFDRSECKEKPSKPTEKT EESKAAAPAPVSEAVCRTSMCSIQS APPEPATLKGTVPDDAVEALADSLG KKEADPEDGKPVMDKVKEKAKEEDR EKLGEKEETIPPDYRLEEVKDKDGK PLLPKESKEQLPPMSEDFLLDALSE DFSGPQNASSLKFEDAKLAAAISEV VSQTPASTTQAGAPPRDTSQSDKDL DDALDKLSDSLGQRQPDPDENKPME DKVKEKAKAEHRDKLGERDDTIPPE YRHLLDDNGQDKPVKPPTKKSEDSK KPADDQDPIDALSGDLDSCPSTTET SQNTAKDKCKKAASSSKAPKNGGKA KDSAKTTEETSKPKDDTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
