| Description : |
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
99.5 kDa |
| AA Sequence : |
MAGNVKKSSGAGGGSGSGGSGSGGL IGLMKDAFQPHHHHHHHLSPHPPGT VDKKMVEKCWKLMDKVVRLCQNPKL ALKNSPPYILDLLPDTYQHLRTILS RYEGKMETLGENEYFRVFMENLMKK TKQTISLFKEGKERMYEENSQPRRN LTKLSLIFSHMLAELKGIFPSGLFQ GDTFRITKADAAEFWRKAFGEKTIV PWKSFRQALHEVHPISSGLEAMALK STIDLTCNDYISVFEFDIFTRLFQP WSSLLRNWNSLAVTHPGYMAFLTYD EVKARLQKFIHKPGSYIFRLSCTRL GQWAIGYVTADGNILQTIPHNKPLF QALIDGFREGFYLFPDGRNQNPDLT GLCEPTPQDHIKVTQEQYELYCEMG STFQLCKICAENDKDVKIEPCGHLM CTSCLTSWQESEGQGCPFCRCEIKG TEPIVVDPFDPRGSGSLLRQGAEGA PSPNYDDDDDERADDTLFMMKELAG AKVERPPSPFSMAPQASLPPVPPRL DLLPQRVCVPSSASALGTASKAASG SLHKDKPLPVPPTLRDLPPPPPPDR PYSVGAESRPQRRPLPCTPGDCPSR DKLPPVPSSRLGDSWLPRPIPKVPV SAPSSSDPWTGRELTNRHSLPFSLP SQMEPRPDVPRLGSTFSLDTSMSMN SSPLVGPECDHPKIKPSSSANAIYS LAARPLPVPKLPPGEQCEGEEDTEY MTPSSRPLRPLDTSQSSRACDCDQQ IDSCTYEAMYNIQSQAPSITESSTF GEGNLAAAHANTGPEESENEDDGYD VPKPPVPAVLARRTLSDISNASSSF GWLSLDGDPTTNVTEGSQVPERPPK PFPRRINSERKAGSCQQGSGPAASA ATASPQLSSEIENLMSQGYSYQDIQ KALVIAQNNIEMAKNILREFVSISS PAHVATTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
