| Description : |
This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
109.4 kDa |
| AA Sequence : |
MANSMNGRNPGGRGGNPRKGRILGI IDAIQDAVGPPKQAAADRRTVEKTW KLMDKVVRLCQNPKLQLKNSPPYIL DILPDTYQHLRLILSKYDDNQKLAQ LSENEYFKIYIDSLMKKSKRAIRLF KEGKERMYEEQSQDRRNLTKLSLIF SHMLAEIKAIFPNGQFQGDNFRITK ADAAEFWRKFFGDKTIVPWKVFRQC LHEVHQISSGLEAMALKSTIDLTCN DYISVFEFDIFTRLFQPWGSILRNW NFLAVTHPGYMAFLTYDEVKARLQK YSTKPGSYIFRLSCTRLGQWAIGYV TGDGNILQTIPHNKPLFQALIDGSR EGFYLYPDGRSYNPDLTGLCEPTPH DHIKVTQEQYELYCEMGSTFQLCKI CAENDKDVKIEPCGHLMCTSCLTAW QESDGQGCPFCRCEIKGTEPIIVDP FDPRDEGSRCCSIIDPFGMPMLDLD DDDDREESLMMNRLANVRKCTDRQN SPVTSPGSSPLAQRRKPQPDPLQIP HLSLPPVPPRLDLIQKGIVRSPCGS PTGSPKSSPCMVRKQDKPLPAPPPP LRDPPPPPPERPPPIPPDNRLSRHI HHVESVPSKDPPMPLEAWCPRDVFG TNQLVGCRLLGEGSPKPGITASSNV NGRHSRVGSDPVLMRKHRRHDLPLE GAKVFSNGHLGSEEYDVPPRLSPPP PVTTLLPSIKCTGPLANSLSEKTRD PVEEDDDEYKIPSSHPVSLNSQPSH CHNVKPPVRSCDNGHCMLNGTHGPS SEKKSNIPDLSIYLKGDVFDSASDP VPLPPARPPTRDNPKHGSSLNRTPS DYDLLIPPLGEDAFDALPPSLPPPP PPARHSLIEHSKPPGSSSRPSSGQD LFLLPSDPFVDLASGQVPLPPARRL PGENVKTNRTSQDYDQLPSCSDGSQ APARPPKPRPRRTAPEIHHRKPHGP EAALENVDAKIAKLMGEGYAFEEVK RALEIAQNNVEVARSILREFAFPPP VSPRLNLSGPTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
