Recombinant Human CBX7 Protein (1-251 aa), His-tagged

• Cat.No.: CBX7-1353H
• Product Overview: Recombinant Human CBX7 Protein (1-251 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Transcription. Protein Description: Full Length.

Specification

• Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin rodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 30.3 kDa
• Protein length: 1-251 aa
• AA Sequence: MELSAIGEQVFAVESIRKKRVRKGK VEYLVKWKGWPPKYSTWEPEEHILD PRLVMAYEEKEERDRASGYRKRGPK PKRLLLQRLYSMDLRSSHKAKGKEK LCFSLTCPLGSGSPEGVVKAGAPEL VDKGPLVPTLPFPLRKPRKAHKYLR LSRKKFPPRGPNLESHSHRRELFLQ EPPAPDVLQAAGEWEPAAQPPEEEA DADLAEGPPPWTPALPSSEVTVTDI TANSITVTFREAQAAEGFFRDRSGK F
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: CBX7 chromobox homolog 7 [ Homo sapiens ]
• Official Symbol: CBX7
• Synonyms: CBX7; chromobox homolog 7
• Gene ID: 23492
• mRNA Refseq: NM_175709
• Protein Refseq: NP_783640
• MIM: 608457
• UniProt ID: O95931