Recombinant Human CCL2 Protein

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Recombinant Human CCL2 Protein

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Cat.No. : CCL2-0621H
Product Overview : Human CCL2 (P13500, 24 a.a. - 99 a.a.) partial recombinant protein expressed in Escherichia coli.
Description : This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
Source : E. coli
Species : Human
Form : Lyophlized
Bio-activity : Determined by its ability to chemoattract human monocytes using a concentration range of 2.0-40.0 ng/mL.
Molecular Mass : 9 kDa
AA Sequence : QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
Endotoxin : < 0.1 ng/μg (1 EU/μg)
Purity : > 90% by SDS-PAGE and HPLC
Applications : Functional Study
SDS-PAGE
Storage : Store at -20 centigrade on dry atmosphere. After reconstitution with deionized water, store at 4 centigrade for one month. For long term storage store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : Lyophlized from 0.02 M Tris-HCl, pH 7.5 (20% glycerol)
Gene Name : CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ]
Official Symbol : CCL2
Synonyms : CCL2; chemokine (C-C motif) ligand 2; SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); C-C motif chemokine 2; GDCF 2; HC11; MCAF; MCP 1; MCP1; MGC9434; monocyte chemoattractant protein 1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; homologous to mouse Sig je; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys Cys); member 2; SMC CF; small-inducible cytokine A2; monocyte chemoattractant protein-1; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30;
Gene ID : 6347
mRNA Refseq : NM_002982
Protein Refseq : NP_002973
MIM : 158105
UniProt ID : P13500
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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