Recombinant Human CCL28 Protein CCL28-54H

Recombinant Human CCL28 Protein

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Cat.No. : CCL28-54H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human CCL28 Protein was expressed in E. coli.
Description : Human CCL28 is chemokine that is constitutively expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of immune cell types including T-cell subsets and eosinophils through activation of the G protein-coupled receptors CCR10 and CCR3. CCL28 contains an extended C-terminal domain consisting of ~40 flexible amino acids. In addition to the two disulfide bonds that are conserved throughout the chemokine family, two additional cysteine residues at positions 30 and 80 form a novel disulfide linkage between the folded chemokine domain and the flexible C-terminus. Human CCL28 is expressed as an immature polypeptide 127 amino acids in length. Two different mature N-terminal sequences have been described due to uncertainty in the site of cleavage by signal peptidase. CCL28(4-108) is described in the NCIB GenPept entry as the mature form based on an ab initio prediction of the site of signal peptide cleavage. It consists of residues 23-127 of the expressed protein and may exhibit higher potency as a CCR10 agonist than the longer version [CCL28(1-108)] that includes three additional N-terminal residues.
Source : E. coli
Species : Human
Form : Lyophilized
Molecular Mass : 12.070 kDa
Protein length : 114 amino acid
AA Sequence : ILPIASSCCT EVSHHISRRL LERVNMCRIQ RADGDCDLAA VILHVKRRRI CVSPHNHTVK QWMKV QAAKKNGKGN VCHRKKHHGK RNSNRAHQGK HETYGHKTPY
Endotoxin : Endotoxin-free <0.01 EU/ug
Purity : Purity assessed by HPLC, Mass Spectrometry, and NMR
Storage : Store at -20 to -80 centigrade for 12 months; Store at 4 centigrade for 6 months; Store at RT for 1 month.
tmpcolum67 : C-C motif chemokine ligand 28
Figure :

Gene Name : CCL28 C-C motif chemokine ligand 28 [ Homo sapiens (human) ]
Official Symbol : CCL28
Synonyms : MEC; CCK1; SCYA28
Gene ID : 56477
mRNA Refseq : NM_148672
Protein Refseq : NP_683513
MIM : 605240
UniProt ID : Q9NRJ3
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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