| Cat.No. : |
CCL28-54H
Optional Service: Optional requirements on this protein
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| Product Overview : |
Recombinant Human CCL28 Protein was expressed in E. coli. |
| Description : |
Human CCL28 is chemokine that is constitutively expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of immune cell types including T-cell subsets and eosinophils through activation of the G protein-coupled receptors CCR10 and CCR3. CCL28 contains an extended C-terminal domain consisting of ~40 flexible amino acids. In addition to the two disulfide bonds that are conserved throughout the chemokine family, two additional cysteine residues at positions 30 and 80 form a novel disulfide linkage between the folded chemokine domain and the flexible C-terminus. Human CCL28 is expressed as an immature polypeptide 127 amino acids in length. Two different mature N-terminal sequences have been described due to uncertainty in the site of cleavage by signal peptidase. CCL28(4-108) is described in the NCIB GenPept entry as the mature form based on an ab initio prediction of the site of signal peptide cleavage. It consists of residues 23-127 of the expressed protein and may exhibit higher potency as a CCR10 agonist than the longer version [CCL28(1-108)] that includes three additional N-terminal residues. |
| Source : |
E. coli |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
12.070 kDa |
| Protein length : |
114 amino acid |
| AA Sequence : |
ILPIASSCCT EVSHHISRRL LERVNMCRIQ RADGDCDLAA VILHVKRRRI CVSPHNHTVK QWMKV QAAKKNGKGN VCHRKKHHGK RNSNRAHQGK HETYGHKTPY |
| Endotoxin : |
Endotoxin-free <0.01 EU/ug |
| Purity : |
Purity assessed by HPLC, Mass Spectrometry, and NMR |
| Storage : |
Store at -20 to -80 centigrade for 12 months; Store at 4 centigrade for 6 months; Store at RT for 1 month. |
| tmpcolum67 : |
C-C motif chemokine ligand 28 |
| Figure : |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
