Recombinant Human CCL5 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CCL5-2625H
Product Overview : CCL5 MS Standard C13 and N15-labeled recombinant protein (NP_002976) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 10 kDa
AA Sequence : MKVSAAALAVILIATALCAPASASP YSSDTTPCCFAYIARPLPRAHIKEY FYTSGKCSNPAVVFVTRKNRQVCAN PEKKWVREYINSLEMSTRTRPLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : CCL5 C-C motif chemokine ligand 5 [ Homo sapiens (human) ]
Official Symbol : CCL5
Synonyms : CCL5; chemokine (C-C motif) ligand 5; D17S136E, SCYA5, small inducible cytokine A5 (RANTES); C-C motif chemokine 5; beta chemokine RANTES; MGC17164; RANTES; regulated upon activation; normally T expressed; and presumably secreted; SIS delta; SISd; small inducible cytokine subfamily A (Cys Cys); member 5; T cell specific protein p288; T cell specific RANTES protein; TCP228; eoCP; SIS-delta; beta-chemokine RANTES; small-inducible cytokine A5; T-cell specific protein p288; t cell-specific protein P228; T-cell-specific protein RANTES; eosinophil chemotactic cytokine; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted; SCYA5; D17S136E;
Gene ID : 6352
mRNA Refseq : NM_002985
Protein Refseq : NP_002976
MIM : 187011
UniProt ID : P13501

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential clinical applications of CCL5 inhibitors? 10/24/2021

CCL5 inhibitors may be used to control inflammation in diseases like rheumatoid arthritis or as an adjuvant in cancer therapy.

Can CCL5 be used to stimulate the immune system in cancer treatment? 10/24/2020

CCL5-based immunotherapies are being explored to enhance the immune response against cancer cells.

Can CCL5 be used as a diagnostic marker for diseases? 08/14/2019

It can serve as a biomarker for some diseases, but it is usually used in conjunction with other markers for more accurate diagnostics.

What are the clinical implications of elevated CCL5 levels? 02/20/2019

Elevated CCL5 levels are associated with inflammation and may be indicative of certain diseases such as rheumatoid arthritis or HIV infection.

Are there any CCL5-targeted therapies in development? 05/18/2018

Yes, there are ongoing efforts to develop therapies that modulate CCL5 activity, particularly in diseases involving inflammation.

Customer Reviews (3)

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Reviews
08/17/2021

    This specificity enables precise quantification and characterization of CCL5 and its interactions with other molecules or proteins of interest.

    06/23/2019

      Its exceptional performance, coupled with its ability to generate clear and precise protein bands, make it an indispensable tool in achieving accurate and reliable results.

      06/20/2016

        The CCL5 protein exhibits a high degree of specificity in various assays, ensuring accurate and reliable results.

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