Recombinant Human CCNQ Protein (Full length), N-GST-tagged

• Cat.No.: CCNQ-28H
• Product Overview: Recombinant full-length human CyclinM was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: Cyclin M, the only conventional cyclin partner of CDK10, protects CDK10 from ubiquitin-mediated degradation. Cyclin M exhibits strong sequence homology to transcriptional cyclins, especially the L-type cyclins that are associated with CDK11, 12 and 13 to regulate transcription and splicing. CDK10 is required to form a complex with Cyclin M in order to phosphorylate Histone H1, the canonical CDK substrate, and ETS2, a transcription factor that plays key roles in cancer and development.
• Source: Sf9 insect cells
• Species: Human
• Tag: N-GST
• Molecular Mass: Observed MW: ~54 kDa.
  Calculated MW: ~54 kDa.
• Protein Length: Full Length
• Purity: The purity of CyclinM was determined to be > 90 % by densitometry.
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: CCNQ cyclin Q [ Homo sapiens (human) ]
• Official Symbol: CCNQ
• Synonyms: CCNQ; cyclin Q; CycM; FAM58A; cyclin-Q; CDK10-activating cyclin; cyclin M; cyclin-related protein FAM58A; family with sequence similarity 58 member A
• Gene ID: 92002
• mRNA Refseq: NM_152274
• Protein Refseq: NP_689487
• MIM: 300708
• UniProt ID: Q8N1B3