Recombinant Human CCR7 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CCR7-4640H
• Product Overview: CCR7 MS Standard C13 and N15-labeled recombinant protein (NP_001829) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 42.9 kDa
• AA Sequence: MDLGKPMKSVLVVALLVIFQVCLCQ DEVTDDYIGDNTTVDYTLFESLCSK KDVRNFKAWFLPIMYSIICFVGLLG NGLVVLTYIYFKRLKTMTDTYLLNL AVADILFLLTLPFWAYSAAKSWVFG VHFCKLIFAIYKMSFFSGMLLLLCI SIDRYVAIVQAVSAHRHRARVLLIS KLSCVGIWILATVLSIPELLYSDLQ RSSSEQAMRCSLITEHVEAFITIQV AQMVIGFLVPLLAMSFCYLVIIRTL LQARNFERNKAIKVIIAVVVVFIVF QLPYNGVVLAQTVANFNITSSTCEL SKQLNIAYDVTYSLACVRCCVNPFL YAFIGVKFRNDLFKLFKDLGCLSQE QLRQWSSCRHIRRSSMSVEAETTTT FSPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CCR7 C-C motif chemokine receptor 7 [ Homo sapiens (human) ]
• Official Symbol: CCR7
• Synonyms: CCR7; chemokine (C-C motif) receptor 7; CMKBR7, EBI1; C-C chemokine receptor type 7; BLR2; CD197; CDw197; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; CMKBR7
• Gene ID: 1236
• mRNA Refseq: NM_001838
• Protein Refseq: NP_001829
• MIM: 600242
• UniProt ID: P32248