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Recombinant Human CD274 Protein, Biotin Labeled

Cat.No. : CD274-74H
Product Overview : Biotin labeled recombinant Human CD274 Protein without tag was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : Tag free
Purity : > 95% by SDS-PAGE
Quality Control Test : Correct disulfide bonds in PD-L1 were verified by Mass Spectrometry analyses. PD-L1 biotinylation is confirmed by streptavidin binding assay.
Storage : Avoid repeated freeze-thaw cycles. 12 months at -20 to -80 centigrade. 1 month at 2 to 8 centigrade.
Concentration : 0.5 mg/mL
Storage Buffer : 10 mM Bicine buffer at pH8.3, 50% glycerol.
Gene Name : CD274 CD274 molecule [ Homo sapiens (human) ]
Official Symbol : CD274
Synonyms : CD274; CD274 molecule; CD274 antigen, PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296
Gene ID : 29126
mRNA Refseq : NM_014143
Protein Refseq : NP_054862
MIM : 605402
UniProt ID : Q9NZQ7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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