| Description : |
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71.3 kDa |
| AA Sequence : |
MVDYIVEYDYDAVHDDELTIRVGEI IRNVKKLQEEGWLEGELNGRRGMFP DNFVKEIKRETEFKDDSLPIKRERH GNVASLVQRISTYGLPAGGIQPHPQ TKNIKKKTKKRQCKVLFEYIPQNED ELELKVGDIIDINEEVEEGWWSGTL NNKLGLFPSNFVKELEVTDDGETHE AQDDSETVLAGPTSPIPSLGNVSET ASGSVTQPKKIRGIGFGDIFKEGSV KLRTRTSSSETEEKKPEKPLILQSL GPKTQSVEITKTDTEGKIKAKEYCR TLFAYEGTNEDELTFKEGEIIHLIS KETGEAGWWRGELNGKEGVFPDNFA VQINELDKDFPKPKKPPPPAKAPAP KPELIAAEKKYFSLKPEEKDEKSTL EQKPSKPAAPQVPPKKPTPPTKASN LLRSSGTVYPKRPEKPVPPPPPIAK INGEVSSISSKFETEPVSKLKLDSE QLPLRPKSVDFDSLTVRTSKETDVV NFDDIASSENLLHLTANRPKMPGRR LPGRFNGGHSPTHSPEKILKLPKEE DSANLKPSELKKDTCYSPKPSVYLS TPSSASKANTTAFLTPLEIKAKVET DDVKKNSLDELRAQIIELLCIVEAL KKDHGKELEKLRKDLEEEKTMRSNL EMEIEKLKKAVLSSTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
