Recombinant Human CD83 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CD83-5952H
Product Overview : CD83 MS Standard C13 and N15-labeled recombinant protein (NP_001035370) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc&DDK
Molecular Mass : 23 kDa
AA Sequence : MSRGLQLLLLSCAYSLAPATPEVKV ACSEDVDLPCTAPWDPQVPYTVSWV KLLEGGEERMETPQEDHLRGQHYHQ KGQNGSFDAPNERPYSLKIRNTTSC NSGTYRCTLQDPDGQRNLSGKVILR VTGCPAQRKEETFKKYRAEIVLLLA LVIFYLTLIIFTCKFARLQSIFPDF SKAGMERAFLPVTSPNKHLGLVTPH KTELVTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CD83 CD83 molecule [ Homo sapiens (human) ]
Official Symbol : CD83
Synonyms : CD83; CD83 molecule; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily), CD83 molecule; CD83 antigen; BL11; HB15; hCD83; B-cell activation protein; cell surface protein HB15; cell-surface glycoprotein; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily);
Gene ID : 9308
mRNA Refseq : NM_001040280
Protein Refseq : NP_001035370
MIM : 604534
UniProt ID : Q01151

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Customer Reviews (3)

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Reviews
03/16/2021

    The experimental conditions are wide, and the experimental results are accurate and reproducible.

    08/24/2020

      The resulting strips are clear and bright, which greatly exceeds the expected results.

      06/10/2020

        CD83 activity is maintained for a very long time and can be maintained for a long time, which is very stable and reliable.

        Q&As (6)

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        Could CD83 be a target for immunotherapy? 12/19/2021

        Yes, CD83 can be targeted as immunotherapy. Immunotherapy for CD83 has been explored in several clinical trials with some efficacy.

        Are there population differences in CD83 treatment? 10/27/2021

        It is unclear whether there is a population difference in CD83 treatment. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment. Therefore, population-specific treatment strategies may need to be individually adapted and optimized.

        What are possible aspects of future research on CD83? 09/02/2021

        Future research on CD83 may involve more in-depth molecular mechanism studies, optimization and improvement of CD83-based immunotherapy strategies, and research on combination with other immunotherapies or drugs.

        Is there a relationship between CD83 and other immune checkpoint molecules? 03/01/2021

        CD83 interacts and regulates with other immune checkpoint molecules. Together, they are involved in the regulation of the immune response.

        Is CD83 expression regulated by other molecules? 12/20/2020

        Yes, CD83 expression is regulated by a variety of molecules, including cytokines, transcription factors, and epigenetic modifications.

        What is the therapeutic approach for CD83? 08/05/2020

        Current treatments for CD83 mainly include immunotherapy and gene therapy. Immunotherapy against CD83 works primarily by modulating the function of dendritic cells and T cells.

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