Recombinant Human CD86 protein, His-Avi-tagged

• Cat.No.: CD86-580H
• Product Overview: Recombinant human CD86/B7-2 Protein is expressed from mammalian with a His and Avi tag at the C-terminal. It contains Leu26-Pro247.

Specification

• Description: Human B7-H2, also called B7RP-1, B7h, LICOS, and GL50, is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1(PD-L1), PD-L2, and B7-H3. B7 proteins are members of the immunoglobulin(Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. Among the family members, they share about 20-25% amino acid identity. Human and mouse B7-H2 share approximately 49% amino acid identity.
• Source: HEK293
• Species: Human
• Tag: His&Avi
• Form: Supplied as 0.22μm filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 28.2 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
• Protein length: Leu26-Pro247
• Endotoxin: Less than 0.05 EU per μg by the LAL method.
• Purity: >95% as determined by Bis-Tris PAGE; >95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: CD86
• Official Symbol: CD86
• Synonyms: CD86 antigen; CD86 molecule; CD86; B70; B7-2 antigen; B72; B7-2; Activation B7-2 antigen; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; CD28LG2B7-2 antigen); CTLA-4 counter-receptor B7.2; FUN-1; LAB72; MGC34413; T-lymphocyte activation antigen CD86
• Gene ID: 942
• mRNA Refseq: NM_001206924.1
• Protein Refseq: NP_001193853.1
• MIM: 601020
• UniProt ID: P42081

Reviews

01/09/2022

With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

05/30/2021

Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

12/08/2017

The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

Q&As

Are there any ongoing clinical trials involving CD86 inhibitors?

Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.

How does CD86 contribute to transplant medicine?

In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.

How does CD86 influence the balance between Th1 and Th2 immune responses?

CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.

Can CD86 be used as a prognostic marker in certain diseases?

There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.

How does CD86 influence the development of regulatory T cells (Tregs)?

CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.