| Description : |
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71.5 kDa |
| AA Sequence : |
MNLERLRKRVRQYLDQQQYQSALFW ADKVASLSREEPQDIYWLAQCLYLT AQYHRAAHALRSRKLDKLYEACRYL AARCHYAAKEHQQALDVLDMEEPIN KRLFEKYLKDESGFKDPSSDWEMSQ SSIKSSICLLRGKIYDALDNRTLAT YSYKEALKLDVYCFEAFDLLTSHHM LTAQEEKELLESLPLSKLCNEEQEL LRFLFENKLKKYNKPSETVIPESVD GLQENLDVVVSLAERHYYNCDFKMC YKLTSVVMEKDPFHASCLPVHIGTL VELNKANELFYLSHKLVDLYPSNPV SWFAVGCYYLMVGHKNEHARRYLSK ATTLEKTYGPAWIAYGHSFAVESEH DQAMAAYFTAAQLMKGCHLPMLYIG LEYGLTNNSKLAERFFSQALSIAPE DPFVMHEVGVVAFQNGEWKTAEKWF LDALEKIKAIGNEVTVDKWEPLLNN LGHVCRKLKKYAEALDYHRQALVLI PQNASTYSAIGYIHSLMGNFENAVD YFHTALGLRRDDTFSVTMLGHCIEM YIGDSEAYIGADIKDKLKCYDFDVH TMKTLKNIISPPWDFREFEVEKQTA EETGLTPLETSRKTPDSRPSLEETF EIEMNESDMMLETSMSDHSTTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
