| Description : |
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
88.25 kDa |
| AA Sequence : |
MPERLAEMLLDLWTPLIILWITLPP CIYMAPMNQSQVLMSGSPLELNSLG EEQRILNRSKRGWVWNQMFVLEEFS GPEPILVGRLHTDLDPGSKKIKYIL SGDGAGTIFQINDVTGDIHAIKRLD REEKAEYTLTAQAVDWETSKPLEPP SEFIIKVQDINDNAPEFLNGPYHAT VPEMSILGTSVTNVTATDADDPVYG NSAKLVYSILEGQPYFSIEPETAII KTALPNMDREAKEEYLVVIQAKDMG GHSGGLSGTTTLTVTLTDVNDNPPK FAQSLYHFSVPEDVVLGTAIGRVKA NDQDIGENAQSSYDIIDGDGTALFE ITSDAQAQDGIIRLRKPLDFETKKS YTLKVEAANVHIDPRFSGRGPFKDT ATVKIVVEDADEPPVFSSPTYLLEV HENAALNSVIGQVTARDPDITSSPI RFSIDRHTDLERQFNINADDGKITL ATPLDRELSVWHNITIIATEIRNHS QISRVPVAIKVLDVNDNAPEFASEY EAFLCENGKPGQVIQTVSAMDKDDP KNGHYFLYSLLPEMVNNPNFTIKKN EDNSLSILAKHNGFNRQKQEVYLLP IIISDSGNPPLSSTSTLTIRVCGCS NDGVVQSCNVEAYVLPIGLSMGALI AILACIILLLVIVVLFVTLRRHKNE PLIIKDDEDVRENIIRYDDEGGGEE DTEAFDIATLQNPDGINGFLPRKDI KPDLQFMPRQGLAPVPNGVDVDEFI NVRLHEADNDPTAPPYDSIQIYGYE GRGSVAGSLSSLESTTSDSDQNFDY LSDWGPRFKRLGELYSVGESDKETT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
