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Recombinant Human CDNF protein

Cat.No.: CDNF-256H
Product Overview: Recombinant Human CDNF was expressed in CHO.
Description: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
Source: CHO
Species: Human
Form: PBS pH 7.4
Molecular Mass: Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.
Protein length: 163 amino acids
Endotoxin: Less than 1EU/mg of protein as determined by LAL method.
Storage: Store at -70 centigrade upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Concentration: 1 mg/ml Concentration of the protein is determined by BCA Protein Analysis kit (Pierce). BSA was used as a standard.
Gene Name: CDNF cerebral dopamine neurotrophic factor [ Homo sapiens ]
Official Symbol: CDNF
Synonyms: CDNF; cerebral dopamine neurotrophic factor; arginine rich, mutated in early stage tumors like 1 , ARMETL1; conserved dopamine neurotrophic factor; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1;
Gene ID: 441549
mRNA Refseq: NM_001029954
Protein Refseq: NP_001025125
MIM: 611233
UniProt ID: Q49AH0
Chromosome Location: 10p13
Function: growth factor activity;

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