Recombinant Human CDNF protein

• Cat.No.: CDNF-256H
• Product Overview: Recombinant Human CDNF was expressed in CHO.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Protein Length: 163 amino acids
• Description: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
• Form: PBS pH 7.4
• Molecular Mass: Approximately 18.5 kDa, a single non-glycosylated polypeptide chain containing 163 amino acids.
• Endotoxin: Less than 1EU/mg of protein as determined by LAL method.
• Storage: Store at -70 centigrade upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
• Concentration: 1 mg/ml Concentration of the protein is determined by BCA Protein Analysis kit (Pierce). BSA was used as a standard.

Gene Information

• Gene Name: CDNF cerebral dopamine neurotrophic factor [ Homo sapiens ]
• Official Symbol: CDNF
• Synonyms: CDNF; cerebral dopamine neurotrophic factor; arginine rich, mutated in early stage tumors like 1 , ARMETL1; conserved dopamine neurotrophic factor; ARMET-like protein 1; arginine-rich, mutated in early stage tumors-like 1; ARMETL1
• Gene ID: 441549
• mRNA Refseq: NM_001029954
• Protein Refseq: NP_001025125
• MIM: 611233
• UniProt ID: Q49AH0
• Chromosome Location: 10p13
• Function: growth factor activity