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Active Recombinant Human CES1 Protein, His-tagged

Cat.No. : CES1-748H
Product Overview : Recombinant Human CES1 Protein is produced by Baculovirus expression system. This protein is fused with a His tag.
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Description : Carboxylesterase 1, also known as liver carboxylesterase 1 isoform a, is a member of a large family of carboxylesterases. It is also part of the alpha/beta fold hydrolase family. Carboxylesterases hydrolyze long-chain fatty acid esters and thioesters. The resulting carboxylates are then often conjugated by other enzymes to increase solubility and eventually excreted. Also, this enzyme may play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. This protein is known to react aromatic and aliphatic esters and can manage cellular cholesterol esterification levels. It is present in most tissues with higher levels in the liver and low levels in the gastrointestinal tract. Recombinant human Carboxylesterase 1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid. In 25 mM Sodium Acetate (pH 4.0) containing 10 % glycerol, 0.1 M NaCl, 0.1 mM PMSF.
Bio-activity : Specific activity is > 700 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of p-nitrophenyl acetate to pnitrophenol per minute at pH 7.5 at 37 centigrade.
Molecular Mass : 61.7 kDa
Protein length : 19-568 aa
AA Sequence : ADLGHPSSPP VVDTVHGKVL GKFVSLEGFA QPVAIFLGIP FAKPPLGPLR FTPPQPAEPW SFVKNATSYP PMCTQDPKAG QLLSELFTNR KENIPLKLSE DCLYLNIYTP ADLTKKNRLP VMVWIHGGGL MVGAASTYDG LALAAHENVV VVTIQYRLGI WGFFSTGDEH SRGNWGHLDQ VAALRWVQDN IASFGGNPGS VTIFGESAGG ESVSVLVLSP LAKNLFHRAI SESGVALTSV LVKKGDVKPL AEQIAITAGC KTTTSAVMVH CLRQKTEEEL LETTLKMKFL SLDLQGDPRE SQPLLGTVID GMLLLKTPEE LQAERNFHTV PYMVGINKQE FGWLIPMQLM SYPLSEGQLD QKTAMSLLWK SYPLVCIAKE LIPEATEKYL GGTDDTVKKK DLFLDLIADV MFGVPSVIVA RNHRDAGAPT YMYEFQYRPS FSSDMKPKTV IGDHGDELFS VFGAPFLKEG ASEEEIRLSK MVMKFWANFA RNGNPNGEGL PHWPEYNQKE GYLQIGANTQ AAQKLKDKEV AFWTNLFAKK AVEKPPQTEH IELHHHHHH
Endotoxin : < 1.0 EU per 1 ug of protein (determined by LAL method)
Purity : > 90 % by SDS - PAGE
Notes : For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Absorbance at 280 nm)
Gene Name : CES1 carboxylesterase 1 [ Homo sapiens ]
Official Symbol : CES1
Synonyms : Liver carboxylesterase 1 isoform a; CES1; ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH;
Gene ID : 1066
mRNA Refseq : NM_001025194
Protein Refseq : NP_001020365
UniProt ID : P23141

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the CES1 enzyme in the human body? 09/01/2022

CES1 hydrolyzes ester and amide bonds in various compounds, including drugs, xenobiotics, and endogenous molecules.

In which tissues or organs is CES1 most abundantly expressed? 07/10/2021

CES1 is most abundantly expressed in the liver, playing a significant role in first-pass metabolism.

How does CES1 contribute to drug metabolism? 09/14/2020

It metabolizes numerous ester-containing drugs, affecting their pharmacokinetics and pharmacodynamics.

What is the significance of CES1 in the metabolism of prodrugs? 05/04/2020

CES1 is crucial for the activation of certain prodrugs, converting them into their active pharmacological forms.

How can genetic variations in the CES1 gene affect drug response? 03/08/2020

Genetic variations in CES1 can lead to inter-individual differences in drug metabolism, impacting efficacy and toxicity.

Are there known inhibitors or activators of CES1, and how might they influence its activity? 04/06/2019

Certain compounds can inhibit or activate CES1, altering the metabolism of its substrates.

What role does CES1 play in lipid metabolism? 02/13/2018

It participates in the hydrolysis of triglycerides and cholesterol esters, contributing to lipid homeostasis.

Customer Reviews (3)

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03/29/2022

    Reliable for lab work.

    09/16/2021

      Great value for quality.

      09/03/2020

        Good quality, great service.

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