Recombinant Human CES2 Protein

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Recombinant Human CES2 Protein

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Cat.No. : CES2-107H
Product Overview : Recombinant human CES2 protein without tag was expressed in E. coli.
Description : This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Source : E. coli
Species : Human
Bio-activity : CES Activity Data(Unless otherwise stated, all assays are carried out at 30 centigrade in 50 mM potassium phosphate buffer (pH 7.4)/acetonitrile, 98/2 (v/v))
Substrate: 4-nitrophenyl butyrate
Linear with time up to: 5 min(Determined at 90 μM substrate, using a protein concentration of 5 μg/ml)
Linear with protein up to: 10 μg/ml(Determined at 90 μM substrate)
Vmax: 3586 nmol/min/mg protein
Km: 156 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : Protein Concentration: 10 mg/ml
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CES2 carboxylesterase 2 [ Homo sapiens (human) ]
Official Symbol : CES2
Synonyms : CES2; carboxylesterase 2; iCE; CE-2; PCE-2; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2
Gene ID : 8824
mRNA Refseq : NM_001365405
Protein Refseq : NP_001352334
MIM : 605278
UniProt ID : O00748

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