| Description : |
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). |
| Source : |
HEK293 cells |
| Tag : |
HIS |
| Form : |
Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH7.4 |
| Molecular Mass : |
63.5kD |
| AA Sequence : |
EGTLCDFPKIHHGFLYDEEDYNPFS QVPTGEVFYYSCEYNFVSPSKSFWT RITCTEEGWSPTPKCLRMCSFPFVK NGHSESSGLIHLEGDTVQIICNTGY SLQNNEKNISCVERGWSTPPICSFT KGECHVPILEANVDAQPKKESYKVG DVLKFSCRKNLIRVGSDSVQCYQFG WSPNFPTCKGQVRSCGPPPQLSNGE VKEIRKEEYGHNEVVEYDCNPNFII NGPKKIQCVDGEWTTLPTCVEQVKT CGYIPELEYGYVQPSVPPYQHGVSV EVNCRNEYAMIGNNMITCINGIWTE LPMCVATHQLKRCKIAGVNIKTLLK LSGKEFNHNSRIRYRCSDIFRYRHS VCINGKWNPEVDCTEKREQFCPPPP QIPNAQNMTTTVNYQDGEKVAVLCK ENYLLPEAKEIVCKDGRWQSLPRCV ESTAYCGPPPSINNGDTTSFPLSVY PPGSTVTYRCQSFYKLQGSVTVTCR NKQWSEPPRCLDPCVVSEENMNKNN IQLKWRNDGKLYAKTGDAVEFQCKF PHKAMISSPPFRAICQEGKFEYPIC EVDHHHHHH |
| Endotoxin : |
Endotoxin level is <0.1 ng/µg of protein (<1EU/µg). |
| Purity : |
>95% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration : |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
