Recombinant Human CHP2 Protein, GST-Tagged

• Cat.No.: CHP2-1262H
• Product Overview: Human CHP2 full-length ORF (BAG35891.1, 1 a.a. - 196 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 47.96 kDa
• AA Sequence: MGSRSSHAAVIPDGDSIRRETGFSQ ASLLRLHHRFRALDRNKKGYLSRMD LQQIGALAVNPLGDRIIESFFPDGS QRVDFPGFVRVLAHFRPVEDEDTET QDPKKPEPLNSRRNKLHYAFQLYDL DRDGKISRHEMLQVLRLMVGVQVTE EQLENIADRTVQEADEDGDGAVSFV EFTKSLEKMDVEQKMSIRILK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CHP2 calcineurin B homologous protein 2 [ Homo sapiens ]
• Official Symbol: CHP2
• Synonyms: CHP2; calcineurin B homologous protein 2; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520
• Gene ID: 63928
• mRNA Refseq: NM_022097
• Protein Refseq: NP_071380