Recombinant Human CISH Protein (Met1-Leu258), His tagged

• Cat.No.: CISH-1733H
• Product Overview: Recombinant human CISH (Met1-Leu258) fused with His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Met1-Leu258
• Description: Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3/CIS3 contains oneSH2 domain and oneSOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3/CIS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. SOCS3/CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3/CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3/CIS3 regulates IL-6 signaling. SOCS3/CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3/CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 30.29 kDa
• Purity: >90% as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: CISH cytokine inducible SH2-containing protein [ Homo sapiens (human) ]
• Official Symbol: CISH
• Synonyms: CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2
• Gene ID: 1154
• mRNA Refseq: NM_013324
• Protein Refseq: NP_037456
• MIM: 602441
• UniProt ID: Q9NSE2