Recombinant Human CISH Protein (Met1-Leu258), His tagged
Cat.No. : | CISH-1733H |
Product Overview : | Recombinant human CISH (Met1-Leu258) fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3/CIS3 contains oneSH2 domain and oneSOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3/CIS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. SOCS3/CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3/CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3/CIS3 regulates IL-6 signaling. SOCS3/CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3/CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized powder/frozen liquid |
Molecular Mass : | 30.29 kDa |
Protein Length : | Met1-Leu258 |
Purity : | >90% as determined by SDS-PAGE |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | CISH cytokine inducible SH2-containing protein [ Homo sapiens (human) ] |
Official Symbol : | CISH |
Synonyms : | CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2; |
Gene ID : | 1154 |
mRNA Refseq : | NM_013324 |
Protein Refseq : | NP_037456 |
MIM : | 602441 |
UniProt ID : | Q9NSE2 |
Products Types
◆ Recombinant Protein | ||
CISH-1380H | Recombinant Human CISH Protein, GST-tagged | +Inquiry |
CISH-708R | Recombinant Rhesus Macaque CISH Protein, His (Fc)-Avi-tagged | +Inquiry |
CISH-612H | Recombinant Human CISH Protein, His-tagged | +Inquiry |
Cish-613M | Recombinant Mouse Cish Protein, His-tagged | +Inquiry |
CISH-1700M | Recombinant Mouse CISH Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CISH-7488HCL | Recombinant Human CISH 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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