Recombinant Human CLEC4G protein, Fc-tagged
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|Product Overview :||Recombinant Human CLEC4G protein (Lys55-Cys293), fused to human IgG1 Fc tag at N-terminus, was expressed in human 293 cells (HEK293).|
|Description :||C-type lectin superfamily 4, member G (CLEC4G) is also known as liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), which is a member of subgroup II of the C-type (Ca2+-dependent) lectin superfamily. CLEC4G/LSECtin binds to mannose, GlcNAc, and fucose in a Ca2+-dependent manner. In addition, CLEC4G/LSECtin has the ability to bind to surface glycoproteins of enveloped viruses. In particular, interaction of LSECtin with the surface glycoproteins of severe acute respiratory syndrome (SARS) coronavirus and Ebola virus has been described, and LSECtin-mediated infection of cells by Ebola virus has been demonstrated.|
|Tag :||human IgG1 Fc|
|Form :||Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 52.1 kDa. The protein migrates as 58-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||239|
|Endotoxin :||Less than 1.0 EU per ug by the LAL method.|
|Purity :||>85% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of CLEC4G-352H :||
Human LSECtin, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 85%.
|Gene Name :||CLEC4G|
|Official Symbol :||CLEC4G|
|Synonyms :||CLEC4G; C-type lectin domain family 4, member G; C type lectin superfamily 4, member G; C-type lectin domain family 4 member G; LSECtin; UNQ431; C-type lectin superfamily 4, member G; liver and lymph node sinusoidal endothelial cell C-type lectin; LP2698; DTTR431|
|Gene ID :||339390|
|mRNA Refseq :||NM_001244856|
|Protein Refseq :||NP_001231785|
|UniProt ID :||Q6UXB4|
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