Recombinant Human CLN6 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CLN6-112H
• Product Overview: CLN6 MS Standard C13 and N15-labeled recombinant protein (NP_060352) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 35.9 kDa
• AA Sequence: MEATRRRQHLGATGGPGAQLGASFL QARHGSVSADEAARTAPFHLDLWFY FTLQNWVLDFGRPIAMLVFPLEWFP LNKPSVGDYFHMAYNVITPFLLLKL IERSPRTLPRSITYVSIIIFIMGAS IHLVGDSVNHRLLFSGYQHHLSVRE NPIIKNLKPETLIDSFELLYYYDEY LGHCMWYIPFFLILFMYFSGCFTAS KAESLIPGPALLLVAPSGLYYWYLV TEGQIFILFIFTFFAMLALVLHQKR KRLFLDSNGLFLFSSFALTLLLVAL WVAWLWNDPVLRKKYPGVIYVPEPW AFYTLHVSSRHTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CLN6 CLN6 transmembrane ER protein [ Homo sapiens (human) ]
• Official Symbol: CLN6
• Synonyms: CLN6; CLN6 transmembrane ER protein; CLN4A; HsT18960; nclf; ceroid-lipofuscinosis neuronal protein 6; ceroid-lipofuscinosis neuronal 6 late infantile; ceroid-lipofuscinosis, neuronal 6, late infantile
• Gene ID: 54982
• mRNA Refseq: NM_017882
• Protein Refseq: NP_060352
• MIM: 606725
• UniProt ID: Q9NWW5