| Description : |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
55.2 kDa |
| AA Sequence : |
MPGGGASAASGRLLTAAEQRGSREA AGSASRSGFGGSGGGRGGASGPGSG SGGPGGPAGRMSLTPKELSSLLSII SEEAGGGSTFEGLSTAFHHYFSKAD HFRLGSVLVMLLQQPDLLPSAAQRL TALYLLWEMYRTEPLAANPFAASFA HLLNPAPPARGGQEPDRPPLSGFLP PITPPEKFFLSQLMLAPPRELFKKT PRQIALMDVGNMGQSVDISGLQLAL AERQSELPTQSKASFPSILSDPDPD SSNSGFDSSVASQITEALVSGPKPP IESHFRPEFIRPPPPLHICEDELAW LNPTEPDHAIQWDKSMCVKNSTGVE IKRIMAKAFKSPLSSPQQTQLLGEL EKDPKLVYHIGLTPAKLPDLVENNP LVAIEMLLKLMQSSQITEYFSVLVN MDMSLHSMEVVNRLTTAVDLPPEFI HLYISNCISTCEQIKDKYMQNRLVR LVCVFLQSLIRNKIINVQDLFIEVQ AFCIEFSRIREAAGLFRLLKTLDTG ETPSETEMSKTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
