Recombinant Human Colony Stimulating Factor 1 (macrophage)
Cat.No. : | CSF1-5383H |
Product Overview : | Recombinant HumanCSF1 was expressed in Hordeum vulgare (barley grain). Its molecular weight is21000 Dalton. |
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- Gene Information
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Cat. No. : | CSF1-5383H |
Description : | Recombinant humanCSF1 (Macrophage Colony Stimulating Factor) contains 158 amino acids and a 16amino acid Histidine-based tag for a total length of 174 amino acids. Thepredicted molecular weight of the recombinant M-CSF with His tag polypeptideis 20.4 kDa, but the recombinant protein migrates with an apparent molecularmass of 21 kDa in SDS-PAGE. |
Source : | Hordeum vulgare(barley grain). Barley grain exhibits up to 50 times less protease activitythan E. coli or mammalian cells. Barley seed is void of any human or animalviral contaminants that could jeopardize cell culture. |
Species : | Human |
Form : | Lyophilized from a0.2 µm sterile filtered solution in 5 mM Tris-HCl + 80 mM Arginine, pH8.0. |
Molecular Weight : | 21 kDa |
Purity : | > 98% asdetermined by SDS-PAGE analysis |
Biological Activity : | Determined bymeasuring the dose-dependent effect of human M-CSF on proliferation ofM-NFS-60 cells. The ED50 range is 0.51-0.76 ng/ml. |
Endotoxin Level : | < 0.005 ng/µg of CSF1 |
Reconstitution : | Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration of 0.1-0.7 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions. |
Storage : | Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C witha carrier protein (0.1% HSA or BSA) as a stabilizer for long term storage.Please note that theaddition of any carrier protein into this product may produce unwantedendotoxin. This depends upon the particular application employed. |
OfficialSymbol : | CSF1 |
Gene Name : | CSF1 colony stimulating factor 1(macrophage) [ Homo sapiens ] |
Synonyms : | CSF1; colonystimulating factor 1 (macrophage); MCSF; MGC31930; colony stimulating factor1; OTTHUMP00000013363; OTTHUMP00000013364; Macrophage colony stimulatingfactor; M-CSF; CSF-1; Lanimostim |
Gene ID : | 1435 |
mRNA Refseq : | NM_000757 |
Protein Refseq : | NP_000748 |
MIM : | 120420 |
UniProt ID : | P09603 |
Chromosome Location : | 1p21-p13 |
Pathway : | Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response; Hematopoietic celllineage; Integrins in angiogenesis; Integrins in angiogenesis; Osteoclastdifferentiation; Rheumatoid arthritis; Rheumatoid arthritis; Signaling eventsmediated by PTP1B; Signaling events mediated by TCPTP |
Function : | cytokine activity;growth factor activity; macrophage colony stimulating factor receptorbinding; protein binding; protein homodimerization activity |
Products Types
◆ Lysates | ||
CSF1-001MCL | Recombinant Mouse CSF1 cell lysate | +Inquiry |
CSF1-1934HCL | Recombinant Human CSF1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.
Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.
Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.
Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.
Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewThe CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.
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