| Description : |
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. |
| Source : |
E. coli |
| Species : |
Human |
| Molecular Mass : |
105 kDa |
| AA Sequence : |
MSPILGYWKIKGLVQPTRLLLEYLE EKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYI ADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSK LPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPK LVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDGSTSG SGHHHHHHSAGLVPRGSTAIGMKET AAAKFERQHMDSPDLGTGGGSGDDD DKSPMATSGANGPGSATASASNPRK FSEKIALQKQRQAEETAAFEEVMMD IGSTRLQAQKLRLAYTRSSHYGGSL PNVNQIGSGLAEFQSPLHSPLDSSR STRHHGLVERVQRDPRRMVSPLRRY TRHIDSSPYSPAYLSPPPESSWRRT MAWGNFPAEKGQLFRLPSALNRTSS DSALHTSVMNPSPQDTYPGPTPPSI LPSRRGGILDGEMDPKVPAIEENLL DDKHLLKPWDAKKLSSSSSRPRSCE VPGINIFPSPDQPANVPVLPPAMNT GGSLPDLTNLHFPPPLPTPLDPEET AYPSLSGGNSTSNLTHTMTHLGISR GMGLGPGYDAPGLHSPLSHPSLQSS LSNPNLQASLSSPQPQLQGSHSHPS LPASSLARHVLPTTSLGHPSLSAPA LSSSSSSSSTSSPVLGAPSYPASTP GASPHHRRVPLSPLSLLAGPADARR SQQQLPKQFSPTMSPTLSSITQGVP LDTSKLSTDQRLPPYPYSSPSLVLP TQPHTPKSLQQPGLPSQSCSVQSSG GQPPGRQSHYGTPYPPGPSGHGQQS YHRPMSDFNLGNLEQFSMESPSASL VLDPPGFSEGPGFLGGEGPMGGPQD PHTFNHQNLTHCSRHGSGPNIILTG DSSPGFSKEIAAALAGVPGFEVSAA GLELGLGLEDELRMEPLGLEGLNML SDPCALLPDPAVEESFRSDRLQ |
| Purity : |
> 90% by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.155 mg/mL |
| Storage Buffer : |
50mM Tris, 20mM NaCl, pH 8.0 |
