Recombinant Human CRY2 Protein, GST-tagged

• Cat.No.: CRY2-1923H
• Product Overview: Human CRY2 full-length ORF ( NP_066940.1, 1 a.a. - 593 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 93.3 kDa
• AA Sequence: MAATVATAAAVAPAPAPGTDSASSV HWFRKGLRLHDNPALLAAVRGARCV RCVYILDPWFAASSSVGINRWRFLL QSLEDLDTSLRKLNSRLFVVRGQPA DVFPRLFKEWGVTRLTFEYDSEPFG KERDAAIMKMAKEAGVEVVTENSHT LYDLDRIIELNGQKPPLTYKRFQAI ISRMELPKKPVGLVTSQQMESCRAE IQENHDETYGVPSLEELGFPTEGLG PAVWQGGETEALARLDKHLERKAWV ANYERPRMNANSLLASPTGLSPYLR FGCLSCRLFYYRLWDLYKKVKRNST PPLSLFGQLLWREFFYTAATNNPRF DRMEGNPICIQIPWDRNPEALAKWA EGKTGFPWIDAIMTQLRQEGWIHHL ARHAVACFLTRGDLWVSWESGVRVF DELLLDADFSVNAGSWMWLSCSAFF QQFFHCYCPVGFGRRTDPSGDYIRR YLPKLKAFPSRYIYEPWNAPESIQK AAKCIIGVDYPRPIVNHAETSRLNI ERMKQIYQQLSRYRGLCLLASVPSC VEDLSHPVAEPSSSQAGSMSSAGPR PLPSGPASPKRKLEAAEEPPGEELS KRARVAELPTPELPSKDA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CRY2 cryptochrome 2 (photolyase-like) [ Homo sapiens ]
• Official Symbol: CRY2
• Synonyms: CRY2; cryptochrome 2 (photolyase-like); cryptochrome-2; growth-inhibiting protein 37; HCRY2; PHLL2; FLJ10332; KIAA0658
• Gene ID: 1408
• mRNA Refseq: NM_001127457
• Protein Refseq: NP_001120929
• MIM: 603732
• UniProt ID: Q49AN0