| Description : |
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
66.9 kDa |
| AA Sequence : |
MAATVATAAAVAPAPAPGTDSASSV HWFRKGLRLHDNPALLAAVRGARCV RCVYILDPWFAASSSVGINRWRFLL QSLEDLDTSLRKLNSRLFVVRGQPA DVFPRLFKEWGVTRLTFEYDSEPFG KERDAAIMKMAKEAGVEVVTENSHT LYDLDRIIELNGQKPPLTYKRFQAI ISRMELPKKPVGLVTSQQMESCRAE IQENHDETYGVPSLEELGFPTEGLG PAVWQGGETEALARLDKHLERKAWV ANYERPRMNANSLLASPTGLSPYLR FGCLSCRLFYYRLWDLYKKVKRNST PPLSLFGQLLWREFFYTAATNNPRF DRMEGNPICIQIPWDRNPEALAKWA EGKTGFPWIDAIMTQLRQEGWIHHL ARHAVACFLTRGDLWVSWESGVRVF DELLLDADFSVNAGSWMWLSCSAFF QQFFHCYCPVGFGRRTDPSGDYIRR YLPKLKAFPSRYIYEPWNAPESIQK AAKCIIGVDYPRPIVNHAETSRLNI ERMKQIYQQLSRYRGLCLLASVPSC VEDLSHPVAEPSSSQAGSMSSAGPR PLPSGPASPKRKLEAAEEPPGEELS KRARVAELPTPELPSKDATRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
