Recombinant Human CSF1R protein, His-Avi-tagged

• Cat.No.: CSF1R-333H
• Product Overview: Recombinant Human CSF1R Protein is expressed from mammalian with His and Avi Tag at the C-terminal. It contains Ile 20-Glu 512.

Specification

• Description: CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 57.4 KDa. Due to glycosylation, the protein migrates to 75-105 KDa based on Bis-Tris PAGE result.
• Protein length: Ile 20-Glu 512
• Endotoxin: Less than 0.1EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: CSF1R colony stimulating factor 1 receptor [ Homo sapiens (human) ]
• Official Symbol: CSF1R
• Synonyms: CD115 antigen; CD115; c-fms; colony stimulating factor 1 receptor; CSF1R; CSF-1-R; CSFR; EC 2.7.10.1; FMS proto-oncogene; FMSFIM2; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSF R; MCSFR; M-CSFR; Proto-oncogene c-Fms
• Gene ID: 1436
• mRNA Refseq: NM_001288705.3
• Protein Refseq: NP_001275634.1
• MIM: 164770
• UniProt ID: P07333