"CTLA4" Related Products

Recombinant Human CTLA4 protein, His-tagged

Cat.No.: CTLA4-54H
Product Overview: Recombinant human CTLA4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description: CTLA4, also known as cytotoxic T-lymphocyte-associated protein 4, is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. This protein is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)-cell extrinsic control of effector responses. It has been implicated in several autoimmune diseases, such as systemic lupus erythematosus.
Source: Insect cells
Species: Human
Tag: His tag
Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 20% glycerol.
Molecular Mass: 14.6kDa (135aa)18-28KDa (SDS–PAGE under reducing conditions.)
AA Sequence: ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDH HHHHH
Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.25mg/ml (determined by Absorbance at 280nm)
Gene Name: CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ]
Official Symbol: CTLA4
Synonyms: CTLA4; CD; CD28; CD152; GSE; ICOS; GRD4; CTLA-4; IDDM12; CELIAC3
Gene ID: 1493
mRNA Refseq: NM_001037631
Protein Refseq: NP_001032720
MIM:
UniProt ID: P16410
Chromosome Location: 2q33
Pathway: Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
Function: protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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