| Description : |
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
100.1 kDa |
| AA Sequence : |
MTAVHAGNINFKWDPKSLEIRTLAV ERLLEPLVTQVTTLVNTNSKGPSNK KRGRSKKAHVLAASVEQATENFLEK GDKIAKESQFLKEELVAAVEDVRKQ GDLMKAAAGEFADDPCSSVKRGNMV RAARALLSAVTRLLILADMADVYKL LVQLKVVEDGILKLRNAGNEQDLGI QYKALKPEVDKLNIMAAKRQQELKD VGHRDQMAAARGILQKNVPILYTAS QACLQHPDVAAYKANRDLIYKQLQQ AVTGISNAAQATASDDASQHQGGGG GELAYALNNFDKQIIVDPLSFSEER FRPSLEERLESIISGAALMADSSCT RDDRRERIVAECNAVRQALQDLLSE YMGNAGRKERSDALNSAIDKMTKKT RDLRRQLRKAVMDHVSDSFLETNVP LLVLIEAAKNGNEKEVKEYAQVFRE HANKLIEVANLACSISNNEEGVKLV RMSASQLEALCPQVINAALALAAKP QSKLAQENMDLFKEQWEKQVRVLTD AVDDITSIDDFLAVSENHILEDVNK CVIALQEKDVDGLDRTAGAIRGRAA RVIHVVTSEMDNYEPGVYTEKVLEA TKLLSNTVMPRFTEQVEAAVEALSS DPAQPMDENEFIDASRLVYDGIRDI RKAVLMIRTPEELDDSDFETEDFDV RSRTSVQTEDDQLIAGQSARAIMAQ LPQEQKAKIAEQVASFQEEKSKLDA EVSKWDDSGNDIIVLAKQMCMIMME MTDFTRGKGPLKNTSDVISAAKKIA EAGSRMDKLGRTIADHCPDSACKQD LLAYLQRIALYCHQLNICSKVKAEV QNLGGELVVSGVDSAMSLIQAAKNL MNAVVQTVKASYVASTKYQKSQGMA SLNLPAVSWKMKAPEKKPLVKREKQ DETQTKIKRASQKKHVNPVQALSEF KAMDSISGPTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
