Recombinant Human CTSD, His tagged
|Product Overview :||Recombinant Human CTSD (P07339) pro form (Met 1-Leu 412), fused with a polyhistidine tag at the C-terminus, was produced in Human Cell.|
- Gene Information
- Related Products
|Form :||Lyophilized from sterile 50 mM Tris, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
|Molecular Mass :||The secreted recombinant human CTSD (pro form) consists of 405 amino acids and has a predicted molecular mass of 44 kDa. As a result of different glycosylation, the apparent molecular mass of rhCTSD is approximately 40-110 kDa in SDS-PAGE under reducing conditions.|
|Protein Length :||Met 1-Leu 412|
|Endotoxin :||< 1.0 EU per μg protein as determined by the LAL method.|
|Purity :||> 97 % as determined by SDS-PAGE|
|Storage :||Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 36°C before opening to recover the entire contents.|
|Gene Name :||CTSD cathepsin D [ Homo sapiens ]|
|Official Symbol :||CTSD|
|Synonyms :||CTSD; cathepsin D; cathepsin D (lysosomal aspartyl protease) , CPSD; ceroid lipofuscinosis; neuronal 10; CLN10; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; CPSD; MGC2311;|
|Gene ID :||1509|
|mRNA Refseq :||NM_001909|
|Protein Refseq :||NP_001900|
|UniProt ID :||P07339|
|◆ Recombinant Protein|
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|CTSD-2752H||Recombinant Human CTSD Protein, His (Fc)-Avi-tagged||+Inquiry|
|◆ Native Protein|
|CTSD-189H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-1648H||Active Native Human Cathepsin D||+Inquiry|
|CTSD-5325D||Active Native Human CTSD protein||+Inquiry|
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|CTSD-3023MCL||Recombinant Mouse CTSD cell lysate||+Inquiry|
|◆ Assay kits|
|Kit-0264||Cathepsin D Inhibitor Screening Kit||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
There is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)Write a review
Good at western-blot experiments. -
In experiments, the biocompatibility performed well. -
The experimental conditions are broad, and the experimental results are accurate and repeatable. -
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