Recombinant Human CTSL Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human CTSL Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : CTSL-4100H
Product Overview : CTSL1 MS Standard C13 and N15-labeled recombinant protein (NP_666023) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein may be necessary for entry of SARS-CoV-2 (COVID-19 virus) into the cell.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 37.5 kDa
AA Sequence : MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMHNRLY GMNEEGWRRA VWEKNVKMIE LHNQEYREGK HSFTMAMNAF GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS LSEQNLVDCS GPQGNEGCNG GLMDYAFQYV QDNGGLDSEE SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV VGYGFESTES DNNKYWLVKN SWGEEWGMGG YVKMAKDRRN HCGIASAASY PTVTRTRPLE QKLISEEDLA ANDILDYKDD DDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : CTSL cathepsin L [ Homo sapiens (human) ]
Official Symbol : CTSL
Synonyms : CTSL; cathepsin L; MEP; CATL; CTSL1; procathepsin L; cathepsin L1; major excreted protein; EC 3.4.22.15
Gene ID : 1514
mRNA Refseq : NM_145918
Protein Refseq : NP_666023
MIM : 116880
UniProt ID : P07711

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