Recombinant Human CYP2C19 Protein


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Recombinant Human CYP2C19 Protein

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Cat.No. : CYP2C19-75H
Product Overview : Recombinant human CYP2C19 protein and human CYP-reductase without tag were coexpressed in E. coli.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 1284 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Diazepam N-demethylase
Linear with time up to: 15 min(Determined at 20 µM substrate, using a P450 concentration of 25 pmol/ml)
Linear with P450 up to: 100 pmol/ml(Determined at 20 µM substrate, using an incubation time of 5 min)
Vmax: 2.6 pmol/min/pmol CYP
Km: 19 µM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 3.7 nmol/ml
Protein Concentration: 18.3 mg/ml
Specific P450 Content: 202 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP2C19 cytochrome P450 family 2 subfamily C member 19 [ Homo sapiens (human) ]
Official Symbol : CYP2C19
Synonyms : CYP2C19; cytochrome P450 family 2 subfamily C member 19; CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19; cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; S-mephenytoin 4-hydroxylase; cytochrome P-450 II C; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450-11A; cytochrome P450-254C; fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; mephenytoin 4-hydroxylase; microsomal monooxygenase; xenobiotic monooxygenase
Gene ID : 1557
mRNA Refseq : NM_000769
Protein Refseq : NP_000760
MIM : 124020
UniProt ID : P33261

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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