Recombinant Human CYP2D6 Protein CYP2D6-49H

Recombinant Human CYP2D6 Protein


Home / Products / Recombinant Proteins / Recombinant Human CYP2D6 Protein

Recombinant Human CYP2D6 Protein

CYP2D6 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : CYP2D6-49H
Product Overview : Recombinant human CYP2D6 and human CYP-reductase without tag was coexpressed in Escherichia coli.
Amount: 0.5 nmol cytochrome P450
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 811 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Dextromethorphan O-demethylase
Linear with time up to: 8 min(Determined at 0.4 µM substrate, using a P450 concentration of 1 pmol/ml)
Linear with P450 up to: 5 pmol/ml(Determined at 0.4 µM substrate, using an incubation time of 5 min)
Vmax: 9.5 pmol/min/pmol CYP
Km: 0.38 µM
Usage : For laboratory (research) purposes only.
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 1.0 nmol/ml
Protein Concentration: 10.0 mg/ml
Specific P450 Content: 100 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP2D6 cytochrome P450 family 2 subfamily D member 6 [ Homo sapiens (human) ]
Official Symbol : CYP2D6
Synonyms : CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; cytochrome P450 2D6; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450-DB1; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; xenobiotic monooxygenase; EC
Gene ID : 1565
mRNA Refseq : NM_000106
Protein Refseq : NP_000097
MIM : 124030
UniProt ID : P10635

Products Types

◆ Recombinant Protein

CYP2D6-78HRecombinant Human CYP2D6 Protein+Inquiry
CYP2D6-3401HRecombinant Human CYP2D6 Protein, DDK-tagged+Inquiry
CYP2D6-136PRecombinant Pig CYP2D6 Protein+Inquiry
CYP2D6-7965HRecombinant Human CYP2D6 protein, His-tagged+Inquiry
CYP2D6-4143CRecombinant Chicken CYP2D6+Inquiry

See All CYP2D6 Recombinant Protein

◆ Lysates

CYP2D6-7112HCLRecombinant Human CYP2D6 293 Cell Lysate+Inquiry

See All CYP2D6 Lysates

◆ Assay kits

Kit-2135Cytochrome P450 2D6 Inhibitor Screening Kit+Inquiry
Kit-2134Cytochrome P450 2D6 Fluorometric Activity Assay Kit+Inquiry

See All CYP2D6 Assay kits

Related Gene


Online Inquiry

  • Note: There will be extra charge for optional service!
  • Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy