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Active Recombinant Human CYP2D6 Protein

Cat.No. : CYP2D6-49H
Product Overview : Recombinant human CYP2D6 and human CYP-reductase without tag was coexpressed in Escherichia coli.
Amount: 0.5 nmol cytochrome P450
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 811 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Dextromethorphan O-demethylase
Linear with time up to: 8 min(Determined at 0.4 µM substrate, using a P450 concentration of 1 pmol/ml)
Linear with P450 up to: 5 pmol/ml(Determined at 0.4 µM substrate, using an incubation time of 5 min)
Vmax: 9.5 pmol/min/pmol CYP
Km: 0.38 µM
Usage : For laboratory (research) purposes only.
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 1.0 nmol/ml
Protein Concentration: 10.0 mg/ml
Specific P450 Content: 100 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP2D6 cytochrome P450 family 2 subfamily D member 6 [ Homo sapiens (human) ]
Official Symbol : CYP2D6
Synonyms : CYP2D6; cytochrome P450 family 2 subfamily D member 6; CPD6; CYP2D; CYP2DL1; CYPIID6; P450C2D; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; cytochrome P450 2D6; cholesterol 25-hydroxylase; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450-DB1; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; microsomal monooxygenase; nonfunctional cytochrome P450 2D6; xenobiotic monooxygenase; EC 1.14.14.1
Gene ID : 1565
mRNA Refseq : NM_000106
Protein Refseq : NP_000097
MIM : 124030
UniProt ID : P10635

Products Types

◆ Recombinant Protein
CYP2D6-0003H Recombinant Human CYP2D6 Protein (P34-R497), Tag Free +Inquiry
CYP2D6-703H Recombinant Human CYP2D6 Protein, His (Fc)-Avi-tagged +Inquiry
CYP2D6-978R Recombinant Rhesus Macaque CYP2D6 Protein, His (Fc)-Avi-tagged +Inquiry
CYP2D6-0004H Recombinant Human CYP2D6 Protein (P34-R497), His tagged +Inquiry
CYP2D6-136P Recombinant Pig CYP2D6 Protein +Inquiry

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◆ Lysates
CYP2D6-7112HCL Recombinant Human CYP2D6 293 Cell Lysate +Inquiry

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◆ Assay kits
Kit-2135 Cytochrome P450 2D6 Inhibitor Screening Kit +Inquiry
Kit-2134 Cytochrome P450 2D6 Fluorometric Activity Assay Kit +Inquiry

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Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How can knowledge of a patient's CYP2D6 genotype impact drug prescribing? 04/08/2023

Knowing a patient's CYP2D6 genotype can help tailor drug therapy, optimizing dosage and minimizing the risk of adverse effects.

How does genetic variability impact the activity of CYP2D6? 07/19/2022

Genetic variations can result in different CYP2D6 phenotypes, influencing an individual's ability to metabolize drugs efficiently.

Are there specific populations that exhibit higher frequencies of CYP2D6 polymorphisms? 03/21/2021

Certain ethnic groups may have a higher prevalence of CYP2D6 polymorphisms, influencing drug response variability among different populations.

What are the clinical implications of CYP2D6 polymorphisms in drug metabolism? 07/23/2020

CYP2D6 polymorphisms can lead to variations in drug response and efficacy, affecting the dosage and choice of medications for patients.

How can CYP2D6 testing be utilized in personalized medicine? 03/18/2019

CYP2D6 testing can guide personalized medicine by helping clinicians choose the most appropriate medications and dosages for individual patients.

Customer Reviews (3)

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Reviews
01/26/2023

    One remarkable aspect of working with the CYP2D6 protein is the excellent technical support provided by its manufacturer.

    08/15/2022

      The CYP2D6 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/09/2016

        With its reliable performance and consistent results, the CYP2D6 protein provides researchers with the confidence and accuracy required for successful experimentation.

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