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Recombinant Human CYP3A7 Protein
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Cat.No. : | CYP3A7-05H |
Product Overview : | Recombinant human CYP3A7 and human CYP-reductase without tag was coexpressed in Escherichia coli. Amount: 0.5 nmol cytochrome P450 |
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Cytochrome c Reductase Activity: 667 nmol/min/mg protein P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 100 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase]) Activity: Testosterone 6β-hydroxylase Linear with time up to: 8 min(Determined at 32 µM substrate, using a P450 concentration of 50 pmol/ml) Linear with P450 up to: 60 pmol/ml(Determined at 32 µM substrate, using an incubation time of 10 min) Vmax: 2.2 pmol/min/pmol CYP Km: 13 µM |
Usage : | For laboratory (research) purposes only. |
Storage : | Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice. |
Concentration : | P450 Concentration: 1.0 nmol/ml Protein Concentration: 10.0 mg/ml Specific P450 Content: 100 pmol/mg protein |
Storage Buffer : | 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA |
Gene Name : | CYP3A7 cytochrome P450 family 3 subfamily A member 7 [ Homo sapiens (human) ] |
Official Symbol : | CYP3A7 |
Synonyms : | CYP3A7; cytochrome P450 family 3 subfamily A member 7; CP37; CYPIIIA7; P450HLp2; P450-HFLA; P-450111A7; P-450(HFL33); cytochrome P450 3A7; aryl hydrocarbon hydroxylase; cytochrome P450, family 3, subfamily A, polypeptide 7; cytochrome P450, subfamily IIIA, polypeptide 7; cytochrome P450-HFLA; flavoprotein-linked monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase; EC 1.14.14.1 |
Gene ID : | 1551 |
mRNA Refseq : | NM_000765 |
Protein Refseq : | NP_000756 |
MIM : | 605340 |
UniProt ID : | P24462 |
◆ Recombinant Protein
CYP3A7-83H | Recombinant Human CYP3A7 Protein | +Inquiry |
CYP3A7-2277H | Recombinant Human CYP3A7 Protein, GST-tagged | +Inquiry |
CYP3A7-1161R | Recombinant Rhesus monkey CYP3A7 Protein, His-tagged | +Inquiry |
CYP3A7-1147C | Recombinant Chicken CYP3A7 | +Inquiry |
CYP3A7-1524H | Recombinant Human CYP3A7 protein, His-tagged | +Inquiry |
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◆ Lysates
CYP3A7-438HCL | Recombinant Human CYP3A7 cell lysate | +Inquiry |
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CYP2C19CYP2C9CYP2D6CYP2E1CYP3A4CYP1B1CYP24A1CYP2J2CYP46A1CYP7B1CYP1A2CYP19A1CYP26A1CYP26B1CYP2A6CYP3A5CYP3A7CYP4F11CYP4F3CYP7A1CYP2C6CYP3A23/3A1CYP1A1CYP2B6CYP4A11Cyp11a1CYP2C8CYP2D4CYP3A2CYP2C18CYP3A43CYP4B1CYP2U1CYP2W1CYP39A1CYP2D1CYP2R1CYP26C1CYP27A1CYP2S1CYP2C11CYP4V2CYP4X1CYP4Z1CYP11B1CYP19A1BCYP4F12CYP4F2CYP4F22CYP38CYP27B1CYP27C1CYP2A13CYP2A7CYP20A1CYP21A2CYP4F8CYP17A1CYP2C23CYP4A22CYP4F13Cyp2a1Cyp2a12Cyp2b3Cyp2b9Cyp2c12Cyp2c13Cyp2c22Cyp2c29Cyp2c38Cyp2c39Cyp2c40Cyp2c44Cyp2c50Cyp2c54Cyp2d11Cyp2d12Cyp2d2Cyp2d22Cyp2d26Cyp2d3Cyp2d34Cyp2d40Cyp2d5Cyp2d9Cyp2f2Cyp2f4Cyp2g1Cyp2c37Cyp21a1Cyp3a11Cyp3a13Cyp3a16Cyp3a18Cyp3a25Cyp3a41aCyp3a41bCyp3a57Cyp4a31Cyp4a32Cyp4a8Cyp4f1Cyp4f14Cyp4f15Cyp4f17Cyp4f18Cyp4f6Cyp4v3Cyp51CYP8B1Cyp11b2Cyp11b3Cyp2a2Cyp2a22Cyp2a3Cyp2a4Cyp2a5Cyp2ab1Cyp2b1Cyp2b10Cyp2b12Cyp2b13Cyp2b15Cyp2b19Cyp2b21Cyp2b23Cyp2c6v1Cyp2c65Cyp2c66Cyp2c67Cyp2c68Cyp2c69Cyp2c7CYP2F1Cyp2j10Cyp2j12Cyp2j13Cyp2j4Cyp2j8Cyp2j9Cyp2t1Cyp2t4Cyp3a23Cyp3a44Cyp3a62Cyp3a9Cyp4a1Cyp4a12aCyp4a12bCyp4a14Cyp4a2Cyp4a29Cyp4a3Cyp4a30bCyp4f39Cyp4f4Cyp4f40Cyp4f5CYP51A1Cyp3a59CYP1B1-AS1CYP2B7P1
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