Recombinant Human CYP46A1 Protein


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Recombinant Human CYP46A1 Protein

CYP46A1 Related Products

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Cat.No. : CYP46A1-03H
Product Overview : Recombinant human CYP46A1 and human CYP-reductase without tag was coexpressed in Escherichia coli.
Amount: 0.5 nmol cytochrome P450
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 91 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Testosterone 16β-hydroxylase
Linear with time up to: 15 min(Determined at 15 µM substrate, using a P450 concentration of 75 pmol/ml)
Linear with P450 up to: 100 pmol/ml(Determined at 15 µM substrate, using an incubation time of 5 min)
Vmax: 1.1 pmol/min/pmol CYP
Km: 15 µM
Usage : For laboratory (research) purposes only.
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 1.0 nmol/ml
Protein Concentration: 10.0 mg/ml
Specific P450 Content: 100 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP46A1 cytochrome P450 family 46 subfamily A member 1 [ Homo sapiens (human) ]
Official Symbol : CYP46A1
Synonyms : CYP46A1; cytochrome P450 family 46 subfamily A member 1; CP46; CYP46; cholesterol 24-hydroxylase; CH24H; cholesterol 24-monooxygenase; cholesterol 24S-hydroxylase; cytochrome P450 46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); EC
Gene ID : 10858
mRNA Refseq : NM_006668
Protein Refseq : NP_006659
MIM : 604087
UniProt ID : Q9Y6A2

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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