Recombinant Human CYP4F11 Protein (38-524 aa), His-SUMO-tagged

• Cat.No.: CYP4F11-1130H
• Product Overview: Recombinant Human CYP4F11 Protein (38-524 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Partial.

Specification

• Description: Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation . Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3-hydroxyarachidonate, and 3-hydroxystearate . Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 72.2 kDa
• Protein length: 38-524 aa
• AA Sequence: TYTFYDNCRRLQCFPQPPKQNWFWG HQGLVTPTEEGMKTLTQLVTTYPQG FKLWLGPTFPLLILCHPDIIRPITS ASAAVAPKDMIFYGFLKPWLGDGLL LSGGDKWSRHRRMLTPAFHFNILKP YMKIFNKSVNIMHDKWQRLASEGSA RLDMFEHISLMTLDSLQKCVFSFES NCQEKPSEYIAAILELSAFVEKRNQ QILLHTDFLYYLTPDGQRFRRACHL VHDFTDAVIQERRCTLPTQGIDDFL KNKAKSKTLDFIDVLLLSKDEDGKE LSDEDIRAEADTFMFEGHDTTASGL SWVLYHLAKHPEYQEQCRQEVQELL KDREPIEIEWDDLAQLPFLTMCIKE SLRLHPPVPVISRCCTQDFVLPDGR VIPKGIVCLINIIGIHYNPTVWPDP EVYDPFRFDQENIKERSPLAFIPFS AGPRNCIGQAFAMAEMKVVLALTLL HFRILPTHTEPRRKPELILRAEGGL WLRVEPLGANSQ
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 [ Homo sapiens ]
• Official Symbol: CYP4F11
• Synonyms: CYP4F11; cytochrome P450 4F11; CYPIVF11
• Gene ID: 57834
• mRNA Refseq: NM_001128932
• Protein Refseq: NP_001122404
• MIM: 611517
• UniProt ID: Q9HBI6