Recombinant Human DAB2 Protein, His-tagged

• Cat.No.: DAB2-1306H
• Product Overview: Recombinant Human DAB2 Protein (Asn3-Thr129) with N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 17.7 kDa
  Accurate Molecular Mass: 23 kDa
• Protein length: Asn3-Thr129
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) [ Homo sapiens (human) ]
• Official Symbol: DAB2
• Synonyms: DAB2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); disabled homolog 2; DOC 2; differentially-expressed protein 2; DOC2; DOC-2; FLJ26626
• Gene ID: 1601
• mRNA Refseq: NM_001244871
• Protein Refseq: NP_001231800
• MIM: 601236
• UniProt ID: P98082