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Recombinant Human DDHD1 Protein, GST-tagged

Cat.No. : DDHD1-5190H
Product Overview : Human DDHD1 full-length ORF ( NP_085140.1, 1 a.a. - 872 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene is a member of the intracellular phospholipase A1 gene family. The protein encoded by this gene preferentially hydrolyzes phosphatidic acid. It is a cytosolic protein with some mitochondrial localization, and is thought to be involved in the regulation of mitochondrial dynamics. Overexpression of this gene causes fragmentation of the tubular structures in mitochondria, while depletion of the gene results in mitochondrial tubule elongation. Deletion of this gene in male mice caused fertility defects, resulting from disruption in the organization of the mitochondria during spermiogenesis. In humans, mutations in this gene have been associated with hereditary spastic paraplegia (HSP), also known as Strumpell-Lorrain disease, or, familial spastic paraparesis (FSP). This inherited disorder is characterized by progressive weakness and spasticity of the legs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 123.5 kDa
AA Sequence : MNYPGRGSPRSPEHNGRGGGGGAWE LGSDARPAFGGGVCCFEHLPGGDPD DGDVPLALLRGEPGLHLAPGTDDHN HHLALDPCLSDENYDFSSAESGSSL RYYSEGESGGGGSSLSLHPPQQPPL VPTNSGGGGATGGSPGERKRTRLGG PAARHRYEVVTELGPEEVRWFYKED KKTWKPFIGYDSLRIELAFRTLLQT TGARPQGGDRDGDHVCSPTGPASSS GEDDDEDRACGFCQSTTGHEPEMVE LVNIEPVCVRGGLYEVDVTQGECYP VYWNQADKIPVMRGQWFIDGTWQPL EEEESNLIEQEHLNCFRGQQMQENF DIEVSKSIDGKDAVHSFKLSRNHVD WHSVDEVYLYSDATTSKIARTVTQK LGFSKASSSGTRLHRGYVEEATLED KPSQTTHIVFVVHGIGQKMDQGRII KNTAMMREAARKIEERHFSNHATHV EFLPVEWRSKLTLDGDTVDSITPDK VRGLRDMLNSSAMDIMYYTSPLYRD ELVKGLQQELNRLYSLFCSRNPDFE EKGGKVSIVSHSLGCVITYDIMTGW NPVRLYEQLLQKEEELPDERWMSYE ERHLLDELYITKRRLKEIEERLHGL KASSMTQTPALKFKVENFFCMGSPL AVFLALRGIRPGNTGSQDHILPREI CNRLLNIFHPTDPVAYRLEPLILKR YSNISPVQIHWYNTSNPLPYEHMKP SFLNPAKEPTSVSENEGISTIPSPV TSPVLSRRHYGESITNIGKASILGA ASIGKGLGGMLFSRFGRSSTTQSSE TSKDSMEDEKKPVASPSATTVGTQT LPHSSSGFLDSALELDHRIDFELRE GLVESRYWSAVTSHTAYWSSLDVAL FLLTFMYKHEHDDDAKPNLDPI
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DDHD1 DDHD domain containing 1 [ Homo sapiens (human) ]
Official Symbol : DDHD1
Synonyms : DDHD1; DDHD domain containing 1; SPG28; PAPLA1; PA-PLA1; phospholipase DDHD1; phosphatidic acid-preferring phospholipase A1 homolog; phosphatidic acid-preferring phospholipase A1-like protein; spastic paraplegia 28 (autosomal recessive)
Gene ID : 80821
mRNA Refseq : NM_001160147
Protein Refseq : NP_001153619
MIM : 614603
UniProt ID : Q8NEL9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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